152 375

Cited 0 times in

Bridging the lesioned spinal cord using hydrogel

Authors
Hong, Le Thi Anh
Department
대학원 의생명과학과
Degree
Master (2015)
Table Of Contents
I. INTRODUCTION 1

A. Spinal Cord Injury 1

B. Cavity formation and the importance of bridging lesion after spinal cord injury. 2

C. Bridging cavity using biomaterials 3

D. Injectable hydrogel for contusive injury model 4

E. Aims of Study 5

II. MATERIALS AND METHODS 6

1. Animal and surgical procedures 6

2. Poly (phosphazene) hydrogel injection 6

3. Tissue processing 6

4. Immunohistochemistry 7

5. Three dimensional reconstruction of lesion cavity 7

6. Zymography 7

7. Behavioral assessment 8

III. RESULTS 10

1. Hydrogel injection prevent cavity formation after contusive spinal cord injury 10

2. Hydrogel injection suppress microglial activation 4 week after injection 14

3. Remodelling of extracellular matrix by I-5 injection 16

4. Matrixmetallo-proteinase-9 ( MMP-9) involved in ECM remodelling 20

5. Perivascular fibroblasts are a major source of the newly formed ECM at 1 and 4 week 23

6. I-5 injection promotes functional recovery 25

IV. DISCUSSION 28

V. CONCLUSION 31
Keywords
Spinal cord injuryhydrogelextracullular matrix
Appears in Collections:
Theses > Graduate School of Biomedical Sciences > Master
AJOU Authors
Hong, Le Thi Anh
Full Text Link
Files in This Item:
000000020728.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse