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CSF-1R expression in tumor-associated macrophages is associated with worse prognosis in classical Hodgkin lymphoma.

Authors
Koh, YW; Park, C; Yoon, DH; Suh, C; Huh, J
Citation
American journal of clinical pathology, 141(4):573-583, 2014
Journal Title
American journal of clinical pathology
ISSN
0002-91731943-7722
Abstract
OBJECTIVES:



The aim of this study was to determine the prognostic relevance of colony-stimulating 1 receptor (CSF-1R) expression in both Hodgkin/Reed-Sternberg (HRS) cells and the surrounding cells (non-HRS cells) in patients with classical Hodgkin lymphoma (CHL) .



METHODS:



Diagnostic tissues from 112 patients with CHL treated with doxorubicin, bleomycin, vinblastine, and dacarbazine were evaluated retrospectively by immunohistochemical analysis for CSF-1R and CD68 and CD163 for tissue-associated macrophages.



RESULTS:



High numbers (≥30%) of non-HRS cells expressing CSF-1R conferred inferior event-free survival and overall survival in univariate and multivariate analysis. High numbers of non-HRS cells expressing CSF-1R were significantly associated with a high number of tumor-associated macrophages as detected by CD163 expression (P < .001). In particular, coexpression of CSF-1R and CD163 was associated with a worse survival outcome than either CSF-1R or CD163 expression alone or no expression.



CONCLUSIONS:



Our data demonstrate that a high number of non-HRS cells expressing CSF-1R are correlated with an increased tumor macrophage content and worse survival.
MeSH terms
AdolescentAdultAgedAntigens, CD/geneticsAntigens, Differentiation, Myelomonocytic/geneticsFemaleHodgkin Disease/geneticsHodgkin Disease/mortalityHodgkin Disease/pathologyHumansMacrophages/metabolismMaleMiddle AgedPrognosisReceptor, Macrophage Colony-Stimulating Factor/geneticsReceptors, Cell Surface/geneticsRetrospective StudiesTreatment Outcome
DOI
10.1309/AJCPR92TDDFARISU
PMID
24619759
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
AJOU Authors
고, 영화
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