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Differential expression patterns of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) -1, -4, -5, and -14 in human placenta and gestational trophoblastic diseases.

Authors
Lee, SY; Lee, HS; Gil, M; Kim, CJ; Lee, YH; Kim, KR; Park, CS
Citation
Archives of pathology & laboratory medicine, 138(5):643-650, 2014
Journal Title
Archives of pathology & laboratory medicine
ISSN
0003-99851543-2165
Abstract
CONTEXT:



The ability of intermediate trophoblasts to invade maternal tissue during placentation depends on how well they can degrade the extracellular matrix. Invasion into the extracellular matrix requires many complex proteases. A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) is a novel family of secreted metalloproteinases. The ADAMTS-1, -4, -5, and -14 subtypes are known to be expressed in human placenta, but little is understood about their expression patterns.



OBJECTIVE:



To examine the expression patterns of ADAMTS-1, -4, -5, and -14 in specific human placenta cell types during gestation and in gestational trophoblastic diseases.



DESIGN:



Placental tissues were obtained from 25 pregnant women and 21 cases of gestational trophoblastic diseases (10 early complete moles, 3 placental site trophoblastic tumors, 4 invasive moles, and 4 choriocarcinomas). The expression of the 4 ADAMTS was analyzed by immunohistochemistry.



RESULTS:



ADAMTS-1, -4, -5, and -14 were differentially expressed by the human placenta throughout gestation in a time-specific and cell type-specific manner, as well as in gestational trophoblastic diseases. ADAMTS-1 showed gradually strong staining intensity in gestational trophoblastic diseases according to the invasive potential but showed consistent strong intensity throughout normal placenta. ADAMTS-4 and ADAMTS-5 exhibited higher and restricted expression in first-trimester intermediate trophoblasts. They also exhibited comparably strong expression in gestational trophoblastic diseases. However, ADAMTS-14 expression remained unchanged throughout gestation.



CONCLUSIONS:



The restricted expression pattern of ADAMTS-4 and ADAMTS-5 and their increased expression in gestational trophoblastic diseases suggest that these 2 ADAMTS subtypes are associated with a biological phenotype of trophoblasts involved in human placentation and the development of gestational trophoblastic diseases.
MeSH terms
ADAM Proteins/biosynthesisAdultChoriocarcinoma/metabolismChoriocarcinoma/pathologyFemaleGene Expression RegulationGene Expression Regulation, NeoplasticGestational Trophoblastic Disease/metabolismGestational Trophoblastic Disease/pathologyHumansHydatidiform Mole, Invasive/metabolismHydatidiform Mole, Invasive/pathologyMiddle AgedPlacenta/metabolismPlacenta/pathologyPregnancyProcollagen N-Endopeptidase/biosynthesisUterine Neoplasms/metabolismUterine Neoplasms/pathology
DOI
10.5858/arpa.2012-0227-OA
PMID
24786121
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
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