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Effect of interferon-lambda on replication of hepatitis B virus in human hepatoma cells.

Authors
Hong, SH; Cho, O; Kim, K; Shin, HJ; Kotenko, SV; Park, S
Citation
Virus research, 126(1-2):245-249, 2007
Journal Title
Virus research
ISSN
0168-17021872-7492
Abstract
The antiviral activity of interferon-lambda (IFN-lambda) against several viruses has been reported, but it has not been investigated whether human IFN-lambda can affect replication of the hepatitis B virus (HBV) in human hepatocyte-derived cells. We found that replication of HBV in a human hepatoma cell line was reduced by approximately 30% following treatment with a high concentration of IFN-lambda. Furthermore, we showed that replication of HBV in another human hepatoma cell line was not suppressed by IFN-lambda. However, these cell lines showed a similar level of transcription for the heterodimeric IFN-lambda receptor and the IFN-lambda-induced antiviral proteins. Our results suggest that the antiviral activity of IFN-lambda against HBV may be limited in human cells.
MeSH terms
Antigens, Viral/biosynthesisCell Line, TumorCytokines/pharmacology*Gene ExpressionGenome, Viral/drug effectsHepatitis B virus/drug effects*Hepatitis B virus/geneticsHepatitis B virus/immunologyHepatitis B virus/physiology*HumansInterleukins/pharmacology*Receptors, Interferon/geneticsRecombinant Proteins/pharmacologyTranscription, Genetic/drug effectsVirus Replication/drug effects
DOI
10.1016/j.virusres.2007.03.006
PMID
17451832
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Microbiology
AJOU Authors
김, 경민신, 호준박, 선
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