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Unique features of non-obstructive emphysema and pure airway obstruction.

Authors
Sheen, S  | Sun, JS  | Park, JH  | Oh, YM | Ki, SK | Kim, K  | Park, SB  | Kim, BT  | Lee, M | Jung, YJ  | Chung, WY  | Lee, KS  | Park, KJ  | Hwang, SC
Citation
The international journal of tuberculosis and lung disease, 18(1). : 109-116, 2014
Journal Title
The international journal of tuberculosis and lung disease
ISSN
1027-37191815-7920
Abstract
SETTING: Emphysema without airway obstruction or airway obstruction without

emphysema are often detected clinically, although they are commonly co-existent.

We therefore tested the hypothesis that non-obstructive emphysema and pure airway

obstruction have unique features. METHODS: A case-control observation study was

undertaken retrospectively in a patient cohort at a single centre. Among 2662

subjects who underwent chest computed tomography and pulmonary function tests, we

enrolled 90 patients with non-obstructive emphysema, 119 with pure airway

obstruction, 81 with obstructive emphysema and 2031 subjects as normal controls.

The features of the four groups were analysed and compared. RESULTS: Higher serum

homocysteine (13.4 +/- 7.4 vs. 11.6 +/- 4.6 mol/l), higher rate of osteoporosis

(15.8% vs. 4.5%), higher leukocyte count, higher male ratio, lower serum albumin

and lower body mass index were observed in subjects with non-obstructive

emphysema than in controls (P < 0.05). In multiple logistic regression analysis

of groups without airway obstruction, osteoporosis, hyperhomocysteinaemia,

hypoalbuminaemia and higher leukocyte count were independent factors associated

with non-obstructive emphysema (P < 0.05). CONCLUSION: Hyperhomocysteinaemia,

hypoalbuminaemia, osteoporosis and higher leukocyte count were independent

predictors of non-obstructive emphysema.
MeSH

DOI
10.5588/ijtld.13.0258
PMID
24365562
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pulmonary & Critical Care Medicine
Journal Papers > School of Medicine / Graduate School of Medicine > Radiology
Journal Papers > School of Medicine / Graduate School of Medicine > Family Practice & Community Health
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Science
Ajou Authors
김, 광민  |  김, 범택  |  박, 광주  |  박, 샛별  |  박, 주헌  |  선, 주성  |  신, 승수  |  이, 규성  |  정, 우영  |  정, 윤정  |  황, 성철
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