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Serum angiopoietin-2 as a clinical marker for lung cancer.

Authors
Park, JH; Park, KJ; Kim, YS; Sheen, SS; Lee, KS; Lee, HN; Oh, YJ; Hwang, SC
Citation
Chest, 132(1):200-206, 2007
Journal Title
Chest
ISSN
0012-36921931-3543
Abstract
BACKGROUND: Angiopoietins play a critical role in the angiogenesis related to tumor growth in concert with vascular endothelial growth factor (VEGF), and enhanced expression of angiopoietin-2 has been reported in lung cancer tissue. METHODS: Patients with lung cancer (n = 136) and healthy volunteers (n = 40) were enrolled. Serum angiopoietin-2 and VEGF concentrations were measured using enzyme-linked immunosorbent assay. RESULTS: Patients with lung cancer had higher serum angiopoietin-2 (2,046.3 +/- 1,171.3 pg/mL vs 1,269.8 +/- 494.1 pg/mL, p < 0.001) and VEGF (542.9 +/- 445.8 pg/mL vs 364.7 +/- 185.9 pg/mL, p < 0.05) [mean +/- SD] levels than the control group. Serum angiopoietin-2 and VEGF levels correlated with each other in patients with lung cancer (Spearman r = 0.30, p < 0.001), specifically in non-small cell lung cancer (NSCLC) [n = 110; r = 0.34; p < 0.001] but not in small cell lung cancer (n = 26). With stage progression in NSCLC, serum angiopoietin-2 levels increased, and patients with distant metastasis had higher levels than those without metastasis (p < 0.005). By contrast, serum VEGF level did not increase with stage progression, and only had a trend toward elevation in distant metastasis (p = 0.05). In NSCLC, the low angiopoietin-2 group (< 1,605.5 pg/mL) had a better overall survival compared to the high angiopoietin-2 group (> or = 1,605.5 pg/mL; p < 0.05), although this survival benefit was not maintained after controlling for stage in a multivariate analysis. The angiopoietin-2 levels were higher in NSCLC patients with postoperative recurrence than in those without. CONCLUSIONS: Our study suggests that serum angiopoietin-2 is a useful clinical marker for detecting NSCLC with distant metastasis and is of potential prognostic value.
MeSH terms
AgedAngiopoietin-2/blood*Angiopoietin-2/geneticsCarcinoma, Non-Small-Cell Lung/blood*Carcinoma, Non-Small-Cell Lung/diagnosisCarcinoma, Small Cell/blood*Carcinoma, Small Cell/diagnosisCase-Control StudiesDisease ProgressionFemaleGene Expression Regulation, NeoplasticHumansKaplan-Meier EstimateLung/metabolismLung/pathologyLung Neoplasms/blood*Lung Neoplasms/diagnosisMaleMiddle AgedNeoplasm StagingPrognosisProportional Hazards ModelsVascular Endothelial Growth Factor A/geneticsVascular Endothelial Growth Factor A/metabolism
DOI
10.1378/chest.06-2915
PMID
17505039
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pulmonary & Critical Care Medicine
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Science
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박주헌박광주신승수이규성오윤정황성철
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