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Clinical characteristics of Korean type 2 diabetic patients in 2005.

Authors
Kim, DJ; Song, KE; Park, JW; Cho, HK; Lee, KW; Huh, KB
Citation
Diabetes research and clinical practice, 77(suppl.1):S252-S257, 2007
Journal Title
Diabetes research and clinical practice
ISSN
0168-82271872-8227
Abstract
Korean type 2 diabetics differ from Western diabetics in showing non-obese but centrally obese anthropometry and relatively more insulin secretory defects than insulin resistance. We assessed insulin secretion based on fasting serum C-peptide level and insulin resistance using the short insulin tolerance test (Kitt; rate constant for plasma glucose disappearance) in 1601 type 2 diabetic Korean patients (831 men and 770 women). Insulin secretory defects were catergorized as severe (C-peptide or=1.70 ng/ml). Groups with a Kitt value of less than 2.5%/min were considered insulin-resistant, while those with a Kitt value > or =2.5%/min were considered insulin-sensitive. Overall, 42.5% of patients had a BMI>or =25.0 kg/m(2), and 70.2% had a BMI> or =23.0 kg/m(2); 45.2% (41.7% of men and 58.3% of women) were abdominally obese (waist> or =90 cm in men and 80 cm in women); mean fasting serum C-peptide level was 1.93+/-0.90 ng/ml, and the mean Kitt value was 2.03+/-0.96%/min. Accordingly, 13, 33, and 54% of patients showed a severe, moderate, and mild to non-secretory defect, respectively; 70.6% were insulin-resistant; and 29.4% were insulin-sensitive. Obese type 2 diabetes is recently increasing in Korea, indicating a shift from insulin secretory defects to insulin resistance.
MeSH terms
AdultAgedAnthropometryBlood Glucose/drug effectsBlood Glucose/metabolismBody Mass IndexBody SizeBody WeightC-Peptide/bloodDiabetes Mellitus, Type 2/blood*Diabetes Mellitus, Type 2/physiopathology*FastingFemaleHumansInsulin/pharmacologyInsulin Resistance*KoreaMaleMiddle Aged
DOI
10.1016/j.diabres.2007.01.067
PMID
17459510
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Endocrinology & Metabolism
AJOU Authors
김, 대중이, 관우
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