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Unrelated donor cord blood transplantation for non-malignant disorders in children and adolescents.

Park, M | Lee, YH | Kang, HR | Lee, JW | Kang, HJ | Park, KD | Shin, HY | Ahn, HS | Baek, HJ | Kook, H | Hwang, TJ | Chung, NG | Cho, B | Kim, HK | Lee, SH | Yoo, KH | Sung, KW | Koo, HH | Koh, KN | Im, HJ | Seo, JJ | Park, JE  | Lim, YJ | Lyu, CJ | Lee, JM | Hah, JO
Pediatric transplantation, 18(2). : 221-229, 2014
Journal Title
Pediatric transplantation
This study analyzes the data reported to the Korean Cord Blood Registry between

1994 and 2008, involving children and adolescents with non-malignant diseases.

Sixty-five patients were evaluated in this study: SAA (n = 24), iBMFS, (n = 16),

and primary immune deficiency/inherited metabolic disorder (n = 25). The CI of

neutrophil recovery was 73.3% on day 42. By day 100, the CI of acute grade II-IV

graft-versus-host disease was 32.3%. At a median follow-up of 71 months, five-yr

OS was 50.7%. The survival rate (37.5%) and CI of neutrophil engraftment (37.5%)

were lowest in patients with iBMFS. Deaths were mainly due to infection,

pulmonary complications, and hemorrhage. In a multivariate analysis, the presence

of >3.91 x 10(5) /kg of infused CD34 + cells was the only factor consistently

identified as significantly associated with neutrophil engraftment (p = 0.04) and

OS (p = 0.03). UCBT using optimal cell doses appears to be a feasible therapy for

non-malignant diseases in children and adolescents for whom there is no

appropriate HLA-matched related donor. Strategies to reduce transplant-related

toxicities would improve the outcomes of UCBT in non-malignant diseases.

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Journal Papers > School of Medicine / Graduate School of Medicine > Pediatrics & Adolescent Medicine
Ajou Authors
박, 준은
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