95 481

Cited 0 times in

Wnt inhibitory factor (WIF)-1 promotes melanogenesis in normal human melanocytes.

Authors
Park, TJ  | Kim, M | Kim, H | Park, SY | Park, KC | Ortonne, JP | Kang, HY
Citation
Pigment cell & melanoma research, 27(1). : 72-81, 2014
Journal Title
Pigment cell & melanoma research
ISSN
1755-14711755-148X
Abstract
Wnt signaling plays a role in the differentiation as well as the development of

melanocytes. Using a microarray analysis, hyperpigmentary skin of melasma

expressed high levels of Wnt inhibitory factor-1 (WIF-1) compared with

perilesional normal skin. In this study, the expression and functional roles of

WIF-1 on melanocytes were investigated. WIF-1 was expressed both in the

melanocytes of normal human skin and in cultured melanocytes. The upregulation of

WIF-1 on cultured normal human melanocytes significantly induced expressions of

MITF and tyrosinase, which were associated with increased melanin content and

tyrosinase activity. Consistent with the stimulatory effect of WIF-1, WIF-1 siRNA

reduced melanogenesis in the cells. Moreover, WIF-1 increases pigmentation in

melanocytes co-cultured with WIF-1-overexpressed fibroblasts and of

organ-cultured human skin. These findings suggest that melanocytes express WIF-1

constitutively in vivo and in vitro and that WIF-1 promotes melanogenesis in

normal human melanocytes.
MeSH

DOI
10.1111/pcmr.12168
PMID
24131586
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Biochemistry & Molecular Biology
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
Ajou Authors
강, 희영  |  박, 태준
Full Text Link
Files in This Item:
24131586.pdfDownload
Export

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse