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Serum lycopene, lutein and zeaxanthin, and the risk of Alzheimer's disease mortality in older adults.

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dc.contributor.authorMin, JY-
dc.contributor.authorMin, KB-
dc.date.accessioned2016-11-18T05:04:22Z-
dc.date.available2016-11-18T05:04:22Z-
dc.date.issued2014-
dc.identifier.issn1420-8008-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/12911-
dc.description.abstractBACKGROUND: Oxidative stress is implicated in the pathogenesis of Alzheimer's

disease (AD). Accumulating evidence shows that antioxidant-rich food reduces the

risk of AD by inhibiting oxidative stress. This study investigates whether serum

levels of carotenoids were associated with the risk of AD mortality in a

nationally representative sample of US adults. METHODS: We used data from the

Third Nutrition and Health Examination Survey (NHANES III) database and the

NHANES III Linked Mortality File. A total of 6,958 participants aged older than

50 years were included in this study. RESULTS: We found that high serum levels of

lycopene and lutein+zeaxanthin at baseline were associated with a lower risk of

AD mortality after adjustment for potential covariates. The reduction in the

mortality risk was progressively raised by increasing serum lycopene (HR = 0.26,

95% CI 0.10-0.69) and lutein+zeaxanthin (HR = 0.43, 95% CI 0.22-0.85) levels. In

contrast, no associations with AD mortality were observed for other serum

carotenoids, including alpha-carotene, beta-carotene, and beta-cryptoxanthin.

CONCLUSION: High serum levels of lycopene and lutein+zeaxanthin are associated

with a lower risk of AD mortality in adults. Our findings suggest that a high

intake of lycopene- or lutein+zeaxanthin-rich food may be important for reducing

the AD mortality risk.
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dc.language.isoen-
dc.subject.MESHAged-
dc.subject.MESHAlzheimer Disease-
dc.subject.MESHAntioxidants-
dc.subject.MESHCarotenoids-
dc.subject.MESHHumans-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHLutein-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHNutrition Surveys-
dc.subject.MESHOxidative Stress-
dc.subject.MESHRisk Factors-
dc.subject.MESHRisk Reduction Behavior-
dc.subject.MESHZeaxanthins-
dc.titleSerum lycopene, lutein and zeaxanthin, and the risk of Alzheimer's disease mortality in older adults.-
dc.typeArticle-
dc.identifier.pmid24247062-
dc.identifier.urlhttps://www.karger.com/Article/FullText/356486-
dc.contributor.affiliatedAuthor민, 경복-
dc.type.localJournal Papers-
dc.identifier.doi10.1159/000356486-
dc.citation.titleDementia and geriatric cognitive disorders-
dc.citation.volume37-
dc.citation.number3-4-
dc.citation.date2014-
dc.citation.startPage246-
dc.citation.endPage256-
dc.identifier.bibliographicCitationDementia and geriatric cognitive disorders, 37(3-4). : 246-256, 2014-
dc.identifier.eissn1421-9824-
dc.relation.journalidJ014208008-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Occupational & Environmental Medicine
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