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Reduced lung function, C-reactive protein, and increased risk of cardiovascular mortality

Min, KB  | Min, JY
Circulation journal, 78(9). : 2309-2316, 2014
Journal Title
Circulation journal
BACKGROUND: We explored whether reduced lung function is a predictor of mortality

due to cardiovascular or coronary artery disease (CVD or CAD), and, if this

hypothesis is correct, whether C-reactive protein (CRP), a systemic inflammatory

marker, is responsible for this association in a general population-based cohort.

METHODS AND RESULTS: We used the Third Nutrition and Health Examination Survey

(NHANES III) database and the NHANES III Linked Mortality File. A total of 13,310

participants >/=20 years of age who completed a spirometric test at baseline

examination were included. On comparison of the participants in the lowest forced

vital capacity percent predicted (FVC% pred) quartile with those in the highest

quartile, the hazard ratio (HR) was 2.1 (95% CI: 1.7-2.6) for cardiovascular

mortality and 2.2 (95% CI: 1.6-3.2) for coronary mortality. A similar association

was observed for forced expiratory volume in 1 s percent predicted (FEV1% pred).

When the participants with the highest FVC% pred or FEV1% pred (Q4) and low CRP

cardiovascular mortality was significantly increased in the individuals with the

lowest spirometric volume (Q1), and the risk was prominent in individuals with

high CRP (>0.22 mg/dl). CONCLUSIONS: There is a significant association between

lung function parameters and death from CVD and CAD in the general population.

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Journal Papers > School of Medicine / Graduate School of Medicine > Occupational & Environmental Medicine
Ajou Authors
민, 경복
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