Cited 0 times in Scipus Cited Count

Urinary phthalate metabolites and the risk of low bone mineral density and osteoporosis in older women.

DC Field Value Language
dc.contributor.authorMin, KB-
dc.contributor.authorMin, JY-
dc.date.accessioned2016-11-18T05:26:53Z-
dc.date.available2016-11-18T05:26:53Z-
dc.date.issued2014-
dc.identifier.issn0021-972X-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/12917-
dc.description.abstractCONTEXT: Experimental studies have demonstrated that phthalate exposure is

associated with skeletal malformations and an imbalance in bone homeostasis.

However, few studies have evaluated the association between phthalates and human

bone health. OBJECTIVES: We evaluated whether urinary phthalate metabolites were

associated with total hip and femur neck bone mineral density (BMD) and

osteoporosis in postmenopausal women (>/=50 y old). DESIGN: We analyzed data from

the 2005-2008 National Health and Nutrition Examination Survey (NHANES) for 398

postmenopausal women >/= 50 years of age. Eleven phthalate metabolites were

selected with a detection rate >/= 60% and were categorized into quartiles. Total

hip and femur neck BMD measurements were obtained using dual-energy x-ray

absorptiometry bone densitometry. Osteoporosis was defined based on the World

Health Organization criteria, with thresholds of 0.64 and 0.56 g/cm(2) or less

for the total hip and femur neck, respectively. RESULTS: Increases in the urinary

mono-n-butyl phthalate, mono-(3-carboxypropyl) phthalate, and monobenzyl

phthalate quartiles were significantly associated with reduced total hip or femur

neck BMD. Postmenopausal women with the highest levels of mono-(3-carboxypropyl)

phthalate, mono(carboxyoctyl) phthalate, and the sum of the three

di(2-ethylhexyl) phthalate metabolites were more likely to have an increased risk

for total hip or femur neck osteoporosis than those with the lowest levels of

these metabolites. CONCLUSION: Urinary phthalate metabolites were associated with

low BMD and high osteoporosis risk in postmenopausal women. Our findings suggest

that background phthalate exposure may unfavorably affect bone homeostasis and

BMD in humans.
-
dc.language.isoen-
dc.subject.MESHAged-
dc.subject.MESHBone Density-
dc.subject.MESHCross-Sectional Studies-
dc.subject.MESHDiethylhexyl Phthalate-
dc.subject.MESHFemur Neck-
dc.subject.MESHHip Joint-
dc.subject.MESHHumans-
dc.subject.MESHLuteolysis-
dc.subject.MESHNutrition Surveys-
dc.subject.MESHOsteoporosis-
dc.subject.MESHPhthalic Acids-
dc.subject.MESHPostmenopause-
dc.subject.MESHPrevalence-
dc.subject.MESHRisk Factors-
dc.titleUrinary phthalate metabolites and the risk of low bone mineral density and osteoporosis in older women.-
dc.typeArticle-
dc.identifier.pmid25050905-
dc.identifier.urlhttp://press.endocrine.org/doi/10.1210/jc.2014-2279?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&-
dc.contributor.affiliatedAuthor민, 경복-
dc.type.localJournal Papers-
dc.identifier.doi10.1210/jc.2014-2279-
dc.citation.titleThe Journal of clinical endocrinology and metabolism-
dc.citation.volume99-
dc.citation.number10-
dc.citation.date2014-
dc.citation.startPageE1997-
dc.citation.endPageE2003-
dc.identifier.bibliographicCitationThe Journal of clinical endocrinology and metabolism, 99(10). : E1997-E2003, 2014-
dc.identifier.eissn1945-7197-
dc.relation.journalidJ00021972X-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Occupational & Environmental Medicine
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse