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Pleiotrophin inhibits melanogenesis via Erk1/2-MITF signaling in normal human melanocytes.

Authors
Choi, WJ | Kim, M | Park, JY  | Park, TJ  | Kang, HY
Citation
Pigment cell & melanoma research, 28(1). : 51-60, 2015
Journal Title
Pigment cell & melanoma research
ISSN
1755-14711755-148X
Abstract
Pleiotrophin (PTN) is a secreted heparin-binding protein that is involved in various biological functions of cell growth and differentiation. Little is known about the effects of PTN on the melanocyte function and skin pigmentation. In this study, we investigated whether PTN would affect melanogenesis. PTN was expressed in melanocytes and fibroblasts of human skin. Transfection studies revealed that PTN decreased melanogenesis, probably through MITF degradation via Erk1/2 activation in melanocytes. The inhibitory action of PTN in pigmentation was further confirmed in ex vivo cultured skin and in the melanocytes cocultured with fibroblasts. These findings suggest that PTN is a crucial factor for the regulation of melanogenesis in the skin.
MeSH

DOI
10.1111/pcmr.12309
PMID
25141921
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
Journal Papers > School of Medicine / Graduate School of Medicine > Biochemistry & Molecular Biology
Ajou Authors
강, 희영  |  박, 지윤  |  박, 태준
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