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High circulating microRNA-122 expression is a poor prognostic marker in patients with hepatitis B virus-related hepatocellular carcinoma who undergo radiofrequency ablation.

Authors
Cho, HJ  | Kim, JK  | Nam, JS | Wang, HJ  | Lee, JH  | Kim, BW  | Kim, SS  | Noh, CK  | Shin, SJ  | Lee, KM  | Cho, SW  | Cheong, JY
Citation
Clinical biochemistry, 48(16-17). : 1073-1078, 2015
Journal Title
Clinical biochemistry
ISSN
0009-91201873-2933
Abstract
OBJECTIVES: Aim of this study was to investigate the prognostic potential of plasma microRNA-122 levels in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma after hepatic resection or radiofrequency ablation (RFA).

DESIGN AND METHODS: A total of 120 patients with HBV-related hepatocellular carcinoma who underwent hepatic resection (n=63) or RFA (n=57) were included. The pretreatment plasma microRNA-122 level was assessed using quantitative real time polymerase chain reaction, and the correlation between microRNA-122 expression and various clinical parameters was investigated.

RESULTS: Multivariate Cox regression analysis demonstrated that, in all patients, a low platelet count (<100×10(9)/L), low albumin level (≤3.5g/dL.), and advanced tumor stage (modified Union for International Cancer Control stage III/IV) were independent prognostic factors for disease-free survival, while a low albumin level and advanced tumor stage were independent prognostic factors for overall survival (OS). In a subgroup analysis of patients who underwent RFA, the patients with high miR-122 expression (>100) had significantly lower OS on Kaplan-Meier analysis (P=0.042). Furthermore, high microRNA-122 expression (hazard ratio [HR]=2.67; 95% confidence interval [CI]=1.12-6.35; P=0.026) and advanced tumor stage (HR=2.27; 95% CI=1.23-4.18; P=0.009) were independent risk factors for poor OS in patients treated with RFA. The combination of microRNA-122 and tumor stage resulted in an area under the curve of 0.818 for predicting 1-year OS in patients who underwent RFA.

CONCLUSIONS: High plasma microRNA-122 expression was associated with poor OS in patients with HBV-related hepatocellular carcinoma who underwent RFA.
MeSH

DOI
10.1016/j.clinbiochem.2015.06.019
PMID
26129878
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
Journal Papers > School of Medicine / Graduate School of Medicine > Radiology
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
Ajou Authors
김, 봉완  |  김, 순선  |  김, 재근  |  노, 충균  |  신, 성재  |  왕, 희정  |  이, 기명  |  이, 제희  |  정, 재연  |  조, 성원  |  조, 효정
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