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PPAR-gamma agonist, ciglitazone, increases pigmentation and migration of human melanocytes.

Authors
Lee, JS; Choi, YM; Kang, HY
Citation
Experimental dermatology, 16(2):118-123, 2007
Journal Title
Experimental dermatology
ISSN
0906-67051600-0625
Abstract
Peroxisome proliferator-activated receptors (PPARs) play an important role in cellular responses. It was reported that three subtypes of PPAR are expressed in human melanocytes. In this study, we investigated the effects of the PPAR-gamma agonist, ciglitazone, on pigmentation and migration of human melanocytes. Ciglitazone stimulated the melanin content of cells and cultured skin. This increase in pigmentation was due to the stimulation of tyrosinase activity and expression of tyrosinase and microphthalmia-associated transcription factor protein of the melanocytes. Migration was increased after ciglitazone treatment, which was observed by the Boyden chamber checkerboard analysis and a scratch motility assay. These results suggest the regulatory role of PPAR-gamma in pigmentation and migration of human melanocytes.
MeSH terms
Cell Movement/physiology*Gene ExpressionHumansMelanins/metabolismMelanocytes/metabolismMelanocytes/physiology*Microphthalmia-Associated Transcription Factor/metabolismMonophenol Monooxygenase/metabolismOrgan Culture TechniquesPPAR gamma/agonistsPPAR gamma/physiology*Pigmentation/physiology*Thiazolidinediones/pharmacology
DOI
10.1111/j.1600-0625.2006.00521.x
PMID
17222225
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
AJOU Authors
강, 희영
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