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High expression of Bcl-2 predicts poor outcome in diffuse large B-cell lymphoma patients with low international prognostic index receiving R-CHOP chemotherapy

Authors
Choi, YW  | Ahn, MS  | Choi, JH  | Lee, HW  | Kang, SY  | Jeong, SH  | Park, JS  | Han, JH  | Kim, JH  | Sheen, SS
Citation
International journal of hematology, 103(2). : 210-218, 2016
Journal Title
International journal of hematology
ISSN
0925-57101865-3774
Abstract
The prognostic significance of Bcl-2, Bcl-6, p53, topoisomerase II, and beta-tubulin expression was evaluated in diffuse large B-cell lymphoma (DLBCL) patients treated with cyclophosphamide, doxorubicin, vincristine, prednisolone, and rituximab. Eight-year progression-free survival (PFS, P = 0.006) and overall survival (OS, P = 0.001) of patients with high Bcl-2 expression were significantly inferior to those of patients with low expression without prognostic significance of Bcl-6, p53, topoisomerase II, and beta-tubulin expression. High expression of Bcl-2 was associated with poor PFS (P = 0.045) and OS (P = 0.004) only in patients with low international prognostic index (IPI). In multivariate analysis, high expression of Bcl-2 was a significant independent prognostic factor of poor PFS (P = 0.026) and OS (P = 0.007) along with high IPI. In conclusion, the expression of Bcl-2 may be a useful prognostic factor, especially in DLBCL patients with low IPI.
MeSH

DOI
10.1007/s12185-015-1911-0
PMID
26586460
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Hematology-Oncology
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Journal Papers > School of Medicine / Graduate School of Medicine > Pulmonary & Critical Care Medicine
Ajou Authors
강, 석윤  |  김, 장희  |  박, 준성  |  신, 승수  |  안, 미선  |  이, 현우  |  정, 성현  |  최, 용원  |  최, 진혁  |  한, 재호
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