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MRI-defined versus clinically-defined vascular depression: comparison of prediction of functional disability in the elderly

Chang, KJ | Hong, CH  | Kim, SH | Lee, KS | Roh, HW | Kang, DR  | Choi, SH | Kim, SY | Na, DL | Seo, SW | Kim, DK | Lee, Y  | Chung, YK  | Lim, KY  | Noh, JS  | Son, SJ
Archives of gerontology and geriatrics, 66. : 7-12, 2016
Journal Title
Archives of gerontology and geriatrics
BACKGROUND: We compared the validity of models of subcortical ischemic depression (SID) and depression-executive dysfunction syndrome (DED) in predicting functional disability in the elderly. METHODS: We obtained data from elderly Korean subjects (n=1356) aged 60 years or older at baseline from the CREDOS study from November 2005 to July 2014. A generalized estimating equation (GEE) model was constructed to measure functional disability using instrumental activity of daily living as a primary outcome. A risk factor of interest was SID and DED evaluated by a visual rating scale of deep white matter hyperintensity in MRI, Stroop test and Geriatric Depression Scale (GDS) score. Receiver-operating-characteristic plots and area under the curve (AUC) test were applied to examine the difference of the two definitions of vascular depression with predicted values of functional disability outcome. RESULTS: The mean (SD) follow-up duration of the participants was 1.7 (0.9) years. The GEE model showed that presence of SID at baseline predicted functional disability compared to non-depressed subjects (GDS score: Odds ratio [OR] 1.76: 95% CI 1.23, 2.53: p=0.002). The association was also statistically significant among the DED group (OR 1.48: 95% CI 1.15, 1.92: p=0.003). There were no significant differences in predicting functional disability (95% CI: -0.003 to 0.009, p=0.366) according to AUC differences between SID and DED. CONCLUSIONS: The results will be useful in evaluating the cardinal features of the vascular depression hypothesis in predicting functional disability.

Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Psychiatry & Behavioural Sciences
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Humanities & Social Medicine
Journal Papers > School of Medicine / Graduate School of Medicine > Preventive Medicine & Public Health
Ajou Authors
강, 대용  |  노, 재성  |  손, 상준  |  이, 윤환  |  임, 기영  |  정, 영기  |  홍, 창형
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