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New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
- Authors
- Lu, Y | Day, FR | Gustafsson, S | Buchkovich, ML | Na, J | Bataille, V | Cousminer, DL | Dastani, Z | Drong, AW | Esko, T | Evans, DM | Falchi, M | Feitosa, MF | Ferreira, T | Hedman, AK | Haring, R | Hysi, PG | Iles, MM | Justice, AE | Kanoni, S | Lagou, V | Li, R | Li, X | Locke, A | Lu, C | Magi, R | Perry, JR | Pers, TH | Qi, Q | Sanna, M | Schmidt, EM | Scott, WR | Shungin, D | Teumer, A | Vinkhuyzen, AA | Walker, RW | Westra, HJ | Zhang, M | Zhang, W | Zhao, JH | Zhu, Z | Afzal, U | Ahluwalia, TS | Bakker, SJ | Bellis, C | Bonnefond, A | Borodulin, K | Buchman, AS | Cederholm, T | Choh, AC | Choi, HJ | Curran, JE | de Groot, LC | De Jager, PL | Dhonukshe-Rutten, RA | Enneman, AW | Eury, E | Evans, DS | Forsen, T | Friedrich, N | Fumeron, F | Garcia, ME | Gartner, S | Han, BG | Havulinna, AS | Hayward, C | Hernandez, D | Hillege, H | Ittermann, T | Kent, JW | Kolcic, I | Laatikainen, T | Lahti, J | Mateo Leach, I | Lee, CG | Lee, JY | Liu, T | Liu, Y | Lobbens, S | Loh, M | Lyytikainen, LP | Medina-Gomez, C | Michaelsson, K | Nalls, MA | Nielson, CM | Oozageer, L | Pascoe, L | Paternoster, L | Polasek, O | Ripatti, S | Sarzynski, MA | Shin, CS | Narancic, NS | Spira, D | Srikanth, P | Steinhagen-Thiessen, E | Sung, YJ | Swart, KM | Taittonen, L | Tanaka, T | Tikkanen, E | van der Velde, N | van Schoor, NM | Verweij, N | Wright, AF | Yu, L | Zmuda, JM | Eklund, N | Forrester, T | Grarup, N | Jackson, AU | Kristiansson, K | Kuulasmaa, T | Kuusisto, J | Lichtner, P | Luan, J | Mahajan, A | Mannisto, S | Palmer, CD | Ried, JS | Scott, RA | Stancakova, A | Wagner, PJ | Demirkan, A | Doring, A | Gudnason, V | Kiel, DP | Kuhnel, B | Mangino, M | McKnight, B | Menni, C | O'Connell, JR | Oostra, BA | Shuldiner, AR | Song, K | Vandenput, L | van Duijn, CM | Vollenweider, P | White, CC | Boehnke, M | Boettcher, Y | Cooper, RS | Forouhi, NG | Gieger, C | Grallert, H | Hingorani, A | Jorgensen, T | Jousilahti, P | Kivimaki, M | Kumari, M | Laakso, M | Langenberg, C | Linneberg, A | Luke, A | McKenzie, CA | Palotie, A | Pedersen, O | Peters, A | Strauch, K | Tayo, BO | Wareham, NJ | Bennett, DA | Bertram, L | Blangero, J | Bluher, M | Bouchard, C | Campbell, H | Cho, NH | Cummings, SR | Czerwinski, SA | Demuth, I | Eckardt, R | Eriksson, JG | Ferrucci, L | Franco, OH | Froguel, P | Gansevoort, RT | Hansen, T | Harris, TB | Hastie, N | Heliovaara, M | Hofman, A | Jordan, JM | Jula, A | Kahonen, M | Kajantie, E | Knekt, PB | Koskinen, S | Kovacs, P | Lehtimaki, T | Lind, L | Liu, Y | Orwoll, ES | Osmond, C | Perola, M | Perusse, L | Raitakari, OT | Rankinen, T | Rao, DC | Rice, TK | Rivadeneira, F | Rudan, I | Salomaa, V | Sorensen, TI | Stumvoll, M | Tonjes, A | Towne, B | Tranah, GJ | Tremblay, A | Uitterlinden, AG | van der Harst, P | Vartiainen, E | Viikari, JS | Vitart, V | Vohl, MC | Volzke, H | Walker, M | Wallaschofski, H | Wild, S | Wilson, JF | Yengo, L | Bishop, DT | Borecki, IB | Chambers, JC | Cupples, LA | Dehghan, A | Deloukas, P | Fatemifar, G | Fox, C | Furey, TS | Franke, L | Han, J | Hunter, DJ | Karjalainen, J | Karpe, F | Kaplan, RC | Kooner, JS | McCarthy, MI | Murabito, JM | Morris, AP | Bishop, JA | North, KE | Ohlsson, C | Ong, KK | Prokopenko, I | Richards, JB | Schadt, EE | Spector, TD | Widen, E | Willer,
- Citation
- Nature communications, 7. : 10495-10495, 2016
- Journal Title
- Nature communications
- ISSN
- 2041-1723
- Abstract
- To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 x 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.
- MeSH
- PMID
- 26833246
- Appears in Collections:
- Journal Papers > School of Medicine / Graduate School of Medicine > Preventive Medicine & Public Health
- Ajou Authors
- 조, 남한
- Full Text Link
- Files in This Item:
- 26833246.pdfDownload
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