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Low levels of circulating microRNA-26a/29a as poor prognostic markers in patients with hepatocellular carcinoma who underwent curative treatment

Authors
Cho, HJ  | Kim, SS  | Nam, JS | Kim, JK  | Lee, JH  | Kim, B  | Wang, HJ  | Kim, BW  | Lee, JD | Kang, DY  | Kim, JH | Jae, YM  | Hwang, JC  | Shin, SJ  | Lee, KM  | Cho, SW  | Cheong, JY
Citation
Clinics and research in hepatology and gastroenterology, 41(2). : 181-189, 2017
Journal Title
Clinics and research in hepatology and gastroenterology
ISSN
2210-74012210-741X
Abstract
BACKGROUND/AIMS: We evaluated the prognostic implication of circulating microRNA (miR)-21, miR-26a, and miR-29a in hepatocellular carcinoma (HCC) patients who underwent curative treatment.
METHODS: The study included 120 hepatitis B virus-related HCC patients who underwent hepatic resection (n=63) or radiofrequency ablation (n=57). MiR-21, miR-26a, and miR-29a expression levels in pretreatment plasma and several clinical variables were analyzed to identify prognostic bio-markers.
RESULTS: Old age, low albumin level, low platelet count, advanced tumor stage (modified Union for International Cancer Control stages III, IV), low miR-26a (hazard ratio [HR]=1.72: 95% confidence interval [CI]=1.04-2.83: P=0.035), and low miR-29a (HR=1.75: 95% CI=1.04-2.94: P=0.035) were identified as independent risk factors for predicting poor disease-free survival. Low miR-21, miR-26a, and miR-29a were associated with poor liver transplantation (LT)-free survival in the univariate analysis. Multivariate Cox regression analysis showed that low miR-26a (HR=3.41: 95% CI=1.32-8.82: P=0.011) and low miR-29a (HR=2.75: 95% CI=1.10-6.85: P=0.030), low platelet count, and advanced tumor stage were significantly associated with poor LT-free survival. Remarkable correlation was found between miR-26a and miR-29a (Spearman's rho=0.734, P<0.001).
CONCLUSION: Pretreatment levels of circulating miR-26a and miR-29a are independent prognostic markers for poor disease-free survival and LT-free survival in hepatitis B virus-related HCC patients.
MeSH

DOI
10.1016/j.clinre.2016.09.011
PMID
27839726
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
Journal Papers > School of Medicine / Graduate School of Medicine > Radiology
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Humanities & Social Medicine
Ajou Authors
강, 대용  |  김, 보현  |  김, 봉완  |  김, 순선  |  김, 재근  |  신, 성재  |  양, 민재  |  왕, 희정  |  이, 기명  |  이, 제희  |  정, 재연  |  조, 성원  |  조, 효정  |  황, 재철
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