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Useful Computed Tomography Score for Estimation of Early Neurologic Outcome in Post-Cardiac Arrest Patients With Therapeutic Hypothermia

Lee, KS | Lee, SE  | Choi, JY  | Gho, YR | Chae, MK  | Park, EJ  | Choi, MH  | Hong, JM
Circulation journal, 81(11). : 1628-1635, 2017
Journal Title
Circulation journal
BACKGROUND: The Alberta Stroke Program Early CT Score (ASPECTS) is used to assess early ischemic stroke damage. This study compared bilateral ASPECTS (ASPECTS-b) with the gray:white matter ratio (GWR) and quantitative regional abnormality (QRA) to evaluate the prognostic utility of early computed tomography (CT) findings in post-cardiac arrest patients.
Methods and Results:Out-of-hospital cardiac arrest patients with return of spontaneous circulation (ROSC) who underwent brain CT (<6 h after onset) and therapeutic hypothermia were recruited from a university hospital over a 2-year period. General demographics, ROSC characteristics, ASPECTS-b (total score=20 points), GWR, and QRA were assessed. Multivariate logistic regression analysis was used to predict neurologic outcome using cerebral performance category (CPC) at 1 month. The study population was divided into good (n=20: CPC 1-2) and poor (n=47: CPC 3-5) outcome groups. The good (vs. poor) outcome group was younger (mean [+/-SD] age 46.7+/-11.8 vs. 60.3+/-17.2 years: P=0.002) and had more initial shockable rhythms (40.0% vs. 8.5%: P=0.002). In addition, the good outcome group had a higher mean ASPECTS-b score (15.3+/-2.7 vs. 9.0+/-4.9: P<0.001), despite no differences in QRA and mean GWR. Age and ASPECTS-b were independent predictors of outcome after adjusting for potential confounders.
CONCLUSIONS: These findings suggest that an initial CT score (ASPECTS-b) could help estimate early neurologic outcomes in post-cardiac arrest patients treated with therapeutic hypothermia.

Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Emergency Medicine
Journal Papers > School of Medicine / Graduate School of Medicine > Brain Science
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
Ajou Authors
박, 은정  |  이, 성은  |  최, 문희  |  최, 민정  |  최, 준영  |  홍, 지만
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