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Useful Computed Tomography Score for Estimation of Early Neurologic Outcome in Post-Cardiac Arrest Patients With Therapeutic Hypothermia

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dc.contributor.authorLee, KS-
dc.contributor.authorLee, SE-
dc.contributor.authorChoi, JY-
dc.contributor.authorGho, YR-
dc.contributor.authorChae, MK-
dc.contributor.authorPark, EJ-
dc.contributor.authorChoi, MH-
dc.contributor.authorHong, JM-
dc.date.accessioned2018-08-24T01:49:41Z-
dc.date.available2018-08-24T01:49:41Z-
dc.date.issued2017-
dc.identifier.issn1346-9843-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/16046-
dc.description.abstractBACKGROUND: The Alberta Stroke Program Early CT Score (ASPECTS) is used to assess early ischemic stroke damage. This study compared bilateral ASPECTS (ASPECTS-b) with the gray:white matter ratio (GWR) and quantitative regional abnormality (QRA) to evaluate the prognostic utility of early computed tomography (CT) findings in post-cardiac arrest patients.
Methods and Results:Out-of-hospital cardiac arrest patients with return of spontaneous circulation (ROSC) who underwent brain CT (<6 h after onset) and therapeutic hypothermia were recruited from a university hospital over a 2-year period. General demographics, ROSC characteristics, ASPECTS-b (total score=20 points), GWR, and QRA were assessed. Multivariate logistic regression analysis was used to predict neurologic outcome using cerebral performance category (CPC) at 1 month. The study population was divided into good (n=20: CPC 1-2) and poor (n=47: CPC 3-5) outcome groups. The good (vs. poor) outcome group was younger (mean [+/-SD] age 46.7+/-11.8 vs. 60.3+/-17.2 years: P=0.002) and had more initial shockable rhythms (40.0% vs. 8.5%: P=0.002). In addition, the good outcome group had a higher mean ASPECTS-b score (15.3+/-2.7 vs. 9.0+/-4.9: P<0.001), despite no differences in QRA and mean GWR. Age and ASPECTS-b were independent predictors of outcome after adjusting for potential confounders.
CONCLUSIONS: These findings suggest that an initial CT score (ASPECTS-b) could help estimate early neurologic outcomes in post-cardiac arrest patients treated with therapeutic hypothermia.
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dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHHypothermia, Induced/methods-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeuroimaging/methods-
dc.subject.MESHOut-of-Hospital Cardiac Arrest/diagnostic imaging-
dc.subject.MESHOut-of-Hospital Cardiac Arrest/therapy-
dc.subject.MESHPrognosis-
dc.subject.MESHTomography, X-Ray Computed/methods-
dc.titleUseful Computed Tomography Score for Estimation of Early Neurologic Outcome in Post-Cardiac Arrest Patients With Therapeutic Hypothermia-
dc.typeArticle-
dc.identifier.pmid28592725-
dc.contributor.affiliatedAuthor이, 성은-
dc.contributor.affiliatedAuthor최, 준영-
dc.contributor.affiliatedAuthor최, 민정-
dc.contributor.affiliatedAuthor박, 은정-
dc.contributor.affiliatedAuthor최, 문희-
dc.contributor.affiliatedAuthor홍, 지만-
dc.type.localJournal Papers-
dc.identifier.doi10.1253/circj.CJ-16-1327-
dc.citation.titleCirculation journal-
dc.citation.volume81-
dc.citation.number11-
dc.citation.date2017-
dc.citation.startPage1628-
dc.citation.endPage1635-
dc.identifier.bibliographicCitationCirculation journal, 81(11). : 1628-1635, 2017-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1347-4820-
dc.relation.journalidJ013469843-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Emergency Medicine
Journal Papers > School of Medicine / Graduate School of Medicine > Brain Science
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
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