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CXCR3 ligands in pleural fluid as markers for the diagnosis of tuberculous pleural effusion

Authors
Chung, W; Jung, Y; Lee, K; Park, J; Sheen, S; Park, K
Citation
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 21(12):1300-1306, 2017
Journal Title
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
ISSN
1027-37191815-7920
Abstract
SETTING: A tertiary care academic medical centre.
OBJECTIVE: To evaluate the clinical usefulness of C-X-C motif chemokine receptor 3 (CXCR3) ligands in tuberculous pleural effusion (TPE).
DESIGN: We recruited 336 patients with pleural effusion due to various causes. Concentrations of interferon-gamma (IFN-gamma) and the CXCR3 ligands CXCL9 and CXCL11 were determined using enzyme immunoassays: adenosine deaminase (ADA) activity was measured in pleural fluid and serum.
RESULTS: TPE was diagnosed in 106 patients. Non-TB conditions included lung cancer (n = 95), para-pneumonic effusion (n = 52), non-lung malignancy (n = 30), other exudate (n = 24) and transudate (n = 29) disorders. All marker levels in serum samples and pleural fluid were significantly higher in the TPE group. Analyses of receiver operating characteristic curves for differentiating TPE from non-TB effusions produced the following results for the area under the curve (AUC) for CXCL9, CXCL11, IFN-gamma and ADA, respectively: 0.982, 0.952, 0.982, and 0.952. Marker AUCs in lymphocytic exudates were also high. Combining the levels of CXCL9, IFN-gamma and ADA in pleural fluid improved the diagnostic performance. Serum levels of CXCL9 had the highest AUC (0.848) for diagnosing TPE.
CONCLUSION: Levels of CXR3 ligands in pleural effusion are useful for diagnosing TPE.
MeSH terms
Biomarkers/analysisBlotting, WesternCase-Control StudiesCyclic Nucleotide Phosphodiesterases, Type 5/analysis*Epithelium/enzymology*FemaleFluorescent Antibody TechniqueHumansMiddle AgedNitric Oxide Synthase/analysis*PremenopauseSexual Dysfunction, Physiological/enzymology*Sexual Dysfunction, Physiological/physiopathologyUrinary Incontinence, Stress/enzymology*Urinary Incontinence, Stress/physiopathologyVagina/enzymology*
DOI
10.5588/ijtld.17.0232
PMID
29297451
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pulmonary & Critical Care Medicine
AJOU Authors
정, 우영정, 윤정이, 규성박, 주헌신, 승수박, 광주
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