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Reduction in microalbuminuria by calcium channel blockers in patients with type 2 diabetes mellitus and hypertension-A randomized, open-label, active-controlled, superiority, parallel-group clinical trial

Authors
Hwang, YC | Yoon, KH | Cha, BS | Lee, KW  | Jang, HC | Min, KW | Chung, CH | Lee, MK
Citation
International journal of clinical practice, 71(9). : e12987-e12987, 2017
Journal Title
International journal of clinical practice
ISSN
1368-50311742-1241
Abstract
BACKGROUND: It has been suggested that renoprotection with calcium channel blockers (CCBs) may differ. This study aimed to compare the anti-proteinuric effect of different CCBs in patients with type 2 diabetes (T2D).
METHODS: A multicentre, randomized, open-label, active-controlled study was performed in seven centres in Korea. A total of 74 patients with T2D and microalbuminuria treated with renin-angiotensin system (RAS) blockers were randomized to a cilnidipine 10 mg treatment (n=38) or amlodipine 5 mg treatment (n=36).
RESULTS: Urine albumin to creatinine ratio (ACR) reduction was similar between the two groups at 12 weeks (-53.0+/-123.2 mg/g in cilnidipine group and -35.7+/-83.6 mg/g in amlodipine group, P=.29) or 24 weeks (-57.3+/-106.9 mg/g in cilnidipine group and -20.0+/-110.4 mg/g in amlodipine group, P=.24). In a subgroup analysis, cilnidipine treatment showed a larger ACR reduction than amlodipine treatment at 12 weeks (-84.7+/-106.8 mg/g in cilnidipine group and -9.5+/-79.2 mg/g in amlodipine group, P=.01) and 24 weeks (-84.0+/-111.7 mg/g in cilnidipine group and 14.6+/-119.4 mg/g in amlodipine group, P=.008), particularly in patients with a longer duration of diabetes more than 10 years.
CONCLUSIONS: Cilnidipine did not show any additional anti-albuminuric effect compared with amlodipine in patients with T2D and microalbuminuria treated with an RAS blocker. However, the anti-albuminuric effect of cilnidipine might differ according to the duration of diabetes.
MeSH

DOI
10.1111/ijcp.12987
PMID
28840637
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Endocrinology & Metabolism
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