164 295

Cited 0 times in

The optimal dose of remifentanil for intubation during sevoflurane induction without neuromuscular blockade in children.

Authors
Min, SK; Kwak, YL; Park, SY; Kim, JS; Kim, JY
Citation
Anaesthesia, 62(5):446-450, 2007
Journal Title
Anaesthesia
ISSN
0003-24091365-2044
Abstract
The optimal dose of remifentanil needed to produce successful intubating conditions following inhalation induction of anaesthesia using 5% sevoflurane without the use of neuromuscular blocking drugs, was investigated in 25 children aged 3-10 years. Sixty seconds after inhalation induction of anaesthesia using sevoflurane 5% in 100% oxygen, a predetermined dose of remifentanil was injected over 30 s. The dose of remifentanil was determined using the modified Dixon's up-and-down method (0.2 microg x kg(-1) as a step size). The first patient was tested at 1.0 microg x kg(-1) remifentanil. Ninety seconds following the bolus administration of remifentanil, the child's trachea was intubated. The optimal bolus dose of remifentanil required for successful tracheal intubation was 0.56 (0.15) microg x kg(-1) in 50% of children during inhalation induction using 5% sevoflurane in the absence of neuromuscular blocking drugs. Using probit analysis, the 95% effective dose (ED(95)) of remifentanil was 0.75 microg x kg(-1) (95% confidence limits 0.63-1.38 microg x kg(-1)).
MeSH terms
Analgesics, Opioid/administration & dosage*Anesthetics, Inhalation*Blood Pressure/drug effectsChildChild, PreschoolDose-Response Relationship, DrugDrug Administration ScheduleFemaleHeart Rate/drug effectsHumansIntubation, Intratracheal/methods*MaleMethyl Ethers*Neuromuscular BlockadePiperidines/administration & dosage*Surgical Procedures, Elective
DOI
10.1111/j.1365-2044.2007.05037.x
PMID
17448054
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Anesthesiology & Pain Medicine
AJOU Authors
민, 상기박, 성용김, 진수김, 종엽
Files in This Item:
Full-Text Not Available.txtDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse