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Role of clusterin/progranulin in toluene diisocyanate-induced occupational asthma

DC Field Value Language
dc.contributor.authorChoi, GS-
dc.contributor.authorTrinh, HKT-
dc.contributor.authorYang, EM-
dc.contributor.authorYe, YM-
dc.contributor.authorShin, YS-
dc.contributor.authorKim, SH-
dc.contributor.authorPark, HS-
dc.date.accessioned2019-11-13T00:18:04Z-
dc.date.available2019-11-13T00:18:04Z-
dc.date.issued2018-
dc.identifier.issn1226-3613-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/16850-
dc.description.abstractToluene diisocyanate (TDI) exposure induces oxidative stress and epithelial cell-derived inflammation, which affect the pathogenesis of TDI-induced occupational asthma (TDI-OA). Recent studies suggested a role for clusterin (CLU) and progranulin (PGRN) in oxidative stress-mediated airway inflammation. To evaluate CLU and PGRN involvement in airway inflammation in TDI-OA, we measured their serum levels in patients with TDI-OA, asymptomatic exposed controls (AECs), and unexposed healthy normal controls (NCs). Serum CLU and PGRN levels were significantly lower in the TDI-OA group than in the AEC and NC groups (P < 0.05). The sensitivity and specificity for predicting the TDI-OA phenotype were 72.4% and 53.4% when either CLU or PGRN levels were below the cutoff values (-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAsthma, Occupational/blood-
dc.subject.MESHAsthma, Occupational/chemically induced-
dc.subject.MESHAsthma, Occupational/metabolism-
dc.subject.MESHCell Line-
dc.subject.MESHClusterin/blood-
dc.subject.MESHClusterin/metabolism-
dc.subject.MESHCoculture Techniques-
dc.subject.MESHEndothelial Cells/metabolism-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHInterleukin-8/metabolism-
dc.subject.MESHMale-
dc.subject.MESHNeutrophils/metabolism-
dc.subject.MESHPhenotype-
dc.subject.MESHProgranulins/blood-
dc.subject.MESHProgranulins/metabolism-
dc.subject.MESHProto-Oncogene Proteins/metabolism-
dc.subject.MESHROC Curve-
dc.subject.MESHReactive Oxygen Species/metabolism-
dc.subject.MESHToluene 2,4-Diisocyanate-
dc.subject.MESHTumor Suppressor Proteins/metabolism-
dc.titleRole of clusterin/progranulin in toluene diisocyanate-induced occupational asthma-
dc.typeArticle-
dc.identifier.pmid29717106-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938014/-
dc.contributor.affiliatedAuthor예, 영민-
dc.contributor.affiliatedAuthor신, 유섭-
dc.contributor.affiliatedAuthor김, 승현-
dc.contributor.affiliatedAuthor박, 해심-
dc.type.localJournal Papers-
dc.identifier.doi10.1038/s12276-018-0085-2-
dc.citation.titleExperimental & molecular medicine-
dc.citation.volume50-
dc.citation.number5-
dc.citation.date2018-
dc.citation.startPage58-
dc.citation.endPage58-
dc.identifier.bibliographicCitationExperimental & molecular medicine, 50(5). : 58-58, 2018-
dc.identifier.eissn2092-6413-
dc.relation.journalidJ012263613-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > Hospital > Clinical Trial Center
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