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Role of clusterin/progranulin in toluene diisocyanate-induced occupational asthma

Authors
Choi, GS | Trinh, HKT | Yang, EM | Ye, YM  | Shin, YS  | Kim, SH  | Park, HS
Citation
Experimental & molecular medicine, 50(5). : 58-58, 2018
Journal Title
Experimental & molecular medicine
ISSN
1226-36132092-6413
Abstract
Toluene diisocyanate (TDI) exposure induces oxidative stress and epithelial cell-derived inflammation, which affect the pathogenesis of TDI-induced occupational asthma (TDI-OA). Recent studies suggested a role for clusterin (CLU) and progranulin (PGRN) in oxidative stress-mediated airway inflammation. To evaluate CLU and PGRN involvement in airway inflammation in TDI-OA, we measured their serum levels in patients with TDI-OA, asymptomatic exposed controls (AECs), and unexposed healthy normal controls (NCs). Serum CLU and PGRN levels were significantly lower in the TDI-OA group than in the AEC and NC groups (P < 0.05). The sensitivity and specificity for predicting the TDI-OA phenotype were 72.4% and 53.4% when either CLU or PGRN levels were below the cutoff values (
MeSH

DOI
10.1038/s12276-018-0085-2
PMID
29717106
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > Hospital > Clinical Trial Center
Ajou Authors
김, 승현  |  박, 해심  |  신, 유섭  |  예, 영민
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