192 472

Cited 7 times in

Characteristic patterns of HLA presentation and T cell differentiation in adult-onset Still's disease

Authors
Jung, JY  | Choi, B | Sayeed, HM | Suh, CH  | Kim, YW | Kim, HA  | Sohn, S
Citation
International journal of immunopathology and pharmacology, 32. : 2058738418791284-2058738418791284, 2018
Journal Title
International journal of immunopathology and pharmacology
ISSN
0394-63202058-7384
Abstract
We examined the expression of human leukocyte antigen (HLA) and composition of differentiated T cells in the peripheral blood to understand the characteristics of the immune changes in patients with adult-onset Still's disease (AOSD). This study enrolled patients with AOSD (n = 14), patients with rheumatoid arthritis (RA, n = 20), and healthy controls (HC, n = 20). The percentage of surface-stained cells with HLA-DP, DQ, and DR alleles and the composition of differentiated T cells in peripheral blood leukocytes (PBLs) were evaluated by flow cytometry. AOSD patients exhibited significantly higher percentages of lymphocytes presenting HLA-DP and HLA-DR, and lower percentages of cells presenting HLA-DQ, than RA patients or HC. The proportions of CD4+, CD4+CCR7+, CD4+CD62L-, and CD8+CD62L- cells from PBLs were decreased in AOSD patients relative to RA patients or HCs. By contrast, AOSD patients had higher proportions of CD8+naive T cells in whole blood relative to RA patients or HC. The proportions of CD4+ effector memory T cells, CD8+ naive T cells, and CD8+ effector memory T cells in whole blood cells and CD4+ effector memory T cell in lymphocytes were significantly associated with the systemic score. While the proportions of CD4+, CD8+, CCR7+, CD4+CCR7+, CD4+CD62L-, and CD8+CD62L- cells were significantly decreased in AOSD patients, and the proportion of CD8+naive T cells was elevated in AOSD and correlated with the systemic score. Further studies of a large cohort of AOSD patients will be necessary to evaluate these markers in the pathogenesis of AOSD.
Keywords
MeSH

DOI
10.1177/2058738418791284
PMID
30052100
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
Journal Papers > School of Medicine / Graduate School of Medicine > Microbiology
Ajou Authors
김, 현아  |  서, 창희  |  손, 성향  |  정, 주양
Full Text Link
Files in This Item:
30052100.pdfDownload
Export

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse