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Serum anti-amyloid-beta antibodies and Alzheimer's disease in elderly Korean patients.

Authors
Song, MS; Mook-Jung, I; Lee, HJ; Min, JY; Park, MH
Citation
The Journal of international medical research, 35(3):301-306, 2007
Journal Title
The Journal of international medical research
ISSN
0300-06051473-2300
Abstract
Alzheimer's disease (AD) is characterized by the deposition of senile plaques and neurofibrillary tangles in the brain. The presence of the amyloid-beta (Abeta) peptide in senile plaques seems to play a central role in the neuropathology of AD. Diagnosis of AD involves neuropsychological examinations or magnetic resonance imaging and, to date, a specific diagnostic marker indicating AD has not been found. This study analysed anti-Abeta antibodies from the serum of 153 patients with AD using an enzyme-linked immunosorbent assay method. The levels of anti-Abeta antibody from patients in the control group (n=193) were compared with those of patients with AD. Our results showed a significantly lower anti-Abeta antibody level in patients with AD than in the control group. These results showed that the anti-Abeta antibody level in serum could potentially be used to diagnose the presence of AD.
MeSH terms
AgedAlzheimer Disease/diagnosisAlzheimer Disease/immunology*Amyloid beta-Peptides/immunology*Antibodies/blood*Case-Control StudiesEnzyme-Linked Immunosorbent AssayFemaleHumansKoreaLogistic ModelsMalePredictive Value of TestsRandom Allocation
DOI
10.1177/147323000703500303
PMID
17593857
Appears in Collections:
Journal Papers > College of Nursing Science > Nursing Science
AJOU Authors
송, 미숙
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