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Comparison of the planned one- and elective two-stent techniques in patients with coronary bifurcation lesions with or without acute coronary syndrome from the COBIS II Registry

Kim, MC | Ahn, Y | Sun Sim, D | Joon Hong, Y | Han Kim, J | Ho Jeong, M | Gwon, HC | Kim, HS | Rha, SW | Yoon, JH | Jang, Y | Tahk, SJ  | Seung, KB
Catheterization and cardiovascular interventions, 92(6). : 1050-1060, 2018
Journal Title
Catheterization and cardiovascular interventions
OBJECTIVES: To evaluate the impacts of stent techniques on long-term clinical outcomes after percutaneous coronary intervention (PCI) using drug-eluting stents (DES) for coronary bifurcation lesions in patients with or without acute coronary syndrome (ACS).
BACKGROUND: Few studies have investigated the impacts of stent techniques for treating coronary bifurcation lesions in patients with and without ACS.
METHODS: This multicenter registry enrolled 2,897 patients undergoing PCI with DES for coronary bifurcation lesions. We investigated the impacts of planned one-stent and elective two-stent techniques in patients with (n = 1,798) and those without (n = 1,099) ACS. Primary endpoint was the incidence of 3-year target-lesion failure (TLF), defined as a composite of cardiac death, spontaneous myocardial infarction, and target-lesion revascularization.
RESULTS: The planned one-stent technique reduced TLF rate compared to elective two-stent technique in the ACS cohort (hazard ratio [HR] 0.49: 95% confidence interval [CI] 0.34-0.74: P = 0.001), and not in the non-ACS cohort (HR 0.61: 95% CI 0.35-1.06: P = 0.079). After propensity score matching, the planned one-stent technique had a significantly lower TLF rate (HR 0.47: 95% CI 0.29-0.74: P = 0.001) in patients with ACS, and it also showed a trend toward lower TLF rate with the planned one-stent technique in patients without ACS (9.0 vs. 14.5%, HR 0.59: 95% CI 0.32-1.14: P = 0.116).
CONCLUSIONS: Planned one-stenting reduced TLF in patients with ACS and it also might be beneficial in those without ACS for the treatment of coronary bifurcation lesions.

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Journal Papers > School of Medicine / Graduate School of Medicine > Cardiology
Ajou Authors
탁, 승제
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