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Strong immunoexpression of dickkopf-1 is associated with response to bortezomib in multiple myeloma

Authors
Choi, YW  | Park, JS  | Han, JH  | Kim, JH  | Ahn, MS  | Lee, HW  | Kang, SY  | Choi, JH  | Jeong, SH
Citation
Leukemia & lymphoma, 59(11). : 2670-2678, 2018
Journal Title
Leukemia & lymphoma
ISSN
1042-81941029-2403
Abstract
The predictive significance of osteolysis-related proteins was evaluated in bortezomib-treated multiple myeloma. The clinicopathological characteristics were collected retrospectively. Immunohistochemistry was performed for analyzing receptor activator of NF-kappaB ligand (RANKL), osteoprotegerin (OPG), macrophage inflammatory protein 1 alpha (MIP1alpha), and dickkopf-1 (DKK1) expression. Among clinicopatholgical characteristics, osteolytic lesion was associated with higher response to bortezomib treatment (79% vs. 46%). High DKK1 expression was significantly correlated with osteolytic lesion (p = .003), whereas RANKL, OPG, and MIP1alpha were not. In high DKK1 expression, higher response to bortezomib was observed (84% vs. 44%). In multivariate analysis, high DKK1 expression was associated with better response to bortezomib (p = .005). Patients with high DKK1 expression had longer median progression-free survival (PFS) and overall survival (OS) after bortezomib treatment. In multivariate analysis, high DKK1 expression was an independent prognostic factor of favorable PFS (p = .027) and OS (p = .035). In multiple myeloma treated with bortezomib, expression status of DKK1 may be a useful predictive marker.
Keywords
DOI
10.1080/10428194.2018.1443331
PMID
29582699
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Hematology-Oncology
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Ajou Authors
강, 석윤  |  김, 장희  |  박, 준성  |  안, 미선  |  이, 현우  |  정, 성현  |  최, 용원  |  최, 진혁  |  한, 재호
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