Cited 0 times in Scipus Cited Count

Radical prostatectomy for clinically localized prostate cancer in patients aged 75 years or older: comparison with primary androgen deprivation therapy

DC Field Value Language
dc.contributor.authorRyu, JH-
dc.contributor.authorKim, SJ-
dc.contributor.authorKim, YB-
dc.contributor.authorJung, TY-
dc.contributor.authorKo, WJ-
dc.contributor.authorKim, SI-
dc.contributor.authorKim, DY-
dc.contributor.authorOh, TH-
dc.contributor.authorMoon, KT-
dc.contributor.authorCho, HJ-
dc.contributor.authorCho, JM-
dc.contributor.authorYoo, TK-
dc.date.accessioned2019-11-13T04:27:59Z-
dc.date.available2019-11-13T04:27:59Z-
dc.date.issued2018-
dc.identifier.issn1368-5538-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/17645-
dc.description.abstractOBJECTIVE: To determine whether radical prostatetomy (RP) is suitable for prostate cancer patients with age >/=75 years in comparison to primary androgen deprivation therapy (PADT).
PATIENTS AND METHODS: A cohort study was conducted in clinically localized prostate cancer patients with >/=75 years of age who underwent RP or PADT at six institutions from 2005 to 2013. Patients who had less than 12 months of follow-up, or received neoadjuvant or adjuvant therapy were excluded. We compared clinical characteristics, cancer-specific and overall survivals, and post-treatment complication rates between two groups.
RESULTS: We included 92 and 99 patients in the RP and PADT groups, respectively. In survival analyses, there were no significant differences in cancer-specific and overall survivals (p = .302 and .995, respectively). The incidence of serious adverse events (cardio- or cerebrovascular event, or bone fracture) was higher in the PADT group (p = .001). Multivariable analysis showed that PADT had a worse effect on the serious adverse events (OR 10.12, p = .038).
CONCLUSIONS: In selected elderly patients, RP was safe and effective for treatment of localized prostate cancer, as compared to PADT. Surgical treatment options should be considered in elderly patients with respect to life expectancy, rather than chronological age.
-
dc.language.isoen-
dc.subject.MESHAge Factors-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAndrogen Antagonists-
dc.subject.MESHGonadotropin-Releasing Hormone-
dc.subject.MESHHumans-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHMale-
dc.subject.MESHPostoperative Complications-
dc.subject.MESHProstatectomy-
dc.subject.MESHProstatic Neoplasms-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTreatment Outcome-
dc.titleRadical prostatectomy for clinically localized prostate cancer in patients aged 75 years or older: comparison with primary androgen deprivation therapy-
dc.typeArticle-
dc.identifier.pmid28828908-
dc.subject.keyword75 years or old-
dc.subject.keywordLocalized prostate cancer-
dc.subject.keywordlife expectancy-
dc.subject.keywordprimary androgen deprivation therapy-
dc.subject.keywordradical prostatectomy-
dc.contributor.affiliatedAuthor김, 선일-
dc.type.localJournal Papers-
dc.identifier.doi10.1080/13685538.2017.1365122-
dc.citation.titleThe aging male-
dc.citation.volume21-
dc.citation.number1-
dc.citation.date2018-
dc.citation.startPage17-
dc.citation.endPage23-
dc.identifier.bibliographicCitationThe aging male, 21(1). : 17-23, 2018-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1473-0790-
dc.relation.journalidJ013685538-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Urology
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse