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Development and validation of the Vitiligo Extent Score for a Target Area (VESTA) to assess the treatment response of a target lesion

Authors
Bae, JM; Oh, SH; Kang, HY; Ryoo, YW; Lan, CE; Xiang, LH; Kim, KH; Suzuki, T; Katayama, I; Lee, SC; East Asia Vitiligo Association
Citation
Pigment cell & melanoma research, 32(2):315-319, 2018
Journal Title
Pigment cell & melanoma research
ISSN
1755-14711755-148X
Abstract
Since localized treatment for vitiligo is as essential as systemic treatment, a reliable instrument for target evaluation is needed besides those for whole body evaluation. We developed the Vitiligo Extent Score for a Target Area (VESTA) using reference images of both marginal and perifollicular repigmentation to measure the repigmentation rate (%) in a target lesion. In the validation study, a total of 65 dermatologists in 10 institutes evaluated 17 pairs of vitiligo images (pre- and post-treatment) using both a rough estimate and the VESTA. The VESTA (concordance correlation coefficient: 0.949, 95% confidence interval [CI] 0.942-0.955) was significantly more accurate than the rough estimate (0.896, 95% CI: 0.883-0.908). It was also associated with better inter-rater reliability over the rough estimate, albeit not significant. The VESTA can afford intuitive, convenient, and reliable assessment of the treatment response in a target area, and would be useful in clinical practice as well as retrospective studies.
Keywords
measurementoutcometarget lesiontreatment responsevalidationvitiligo
MeSH terms
HumansImage Processing, Computer-Assisted*Reproducibility of ResultsVitiligo/diagnosis*
DOI
10.1111/pcmr.12730
PMID
30117287
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
AJOU Authors
강, 희영
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