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Cell surface polysaccharides of Bifidobacterium bifidum induce the generation of Foxp3(+) regulatory T cells

Authors
Verma, R; Lee, C; Jeun, EJ; Yi, J; Kim, KS; Ghosh, A; Byun, S; Lee, CG; Kang, HJ; Kim, GC; Jun, CD; Jan, G; Suh, CH; Jung, JY; Sprent, J; Rudra, D; De Castro, C; Molinaro, A; Surh, CD; Im, SH
Citation
Science immunology, 3(28):eaat6975-eaat6975, 2018
Journal Title
Science immunology
ISSN
2470-9468
Abstract
Dysregulation of intestinal microflora is linked to inflammatory disorders associated with compromised immunosuppressive functions of Foxp3(+) T regulatory (Treg) cells. Although mucosa-associated commensal microbiota has been implicated in Treg generation, molecular identities of the "effector" components controlling this process remain largely unknown. Here, we have defined Bifidobacterium bifidum as a potent inducer of Foxp3(+) Treg cells with diverse T cell receptor specificity to dietary antigens, commensal bacteria, and B. bifidum itself. Cell surface beta-glucan/galactan (CSGG) polysaccharides of B. bifidum were identified as key components responsible for Treg induction. CSGG efficiently recapitulated the activity of whole bacteria and acted via regulatory dendritic cells through a partially Toll-like receptor 2-mediated mechanism. Treg cells induced by B. bifidum or purified CSGG display stable and robust suppressive capacity toward experimental colitis. By identifying CSGG as a functional component of Treg-inducing bacteria, our studies highlight the immunomodulatory potential of CSGG and CSGG-producing microbes.
DOI
10.1126/sciimmunol.aat6975
PMID
30341145
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
AJOU Authors
서, 창희정, 주양
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