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Cell surface polysaccharides of Bifidobacterium bifidum induce the generation of Foxp3(+) regulatory T cells

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dc.contributor.authorVerma, R-
dc.contributor.authorLee, C-
dc.contributor.authorJeun, EJ-
dc.contributor.authorYi, J-
dc.contributor.authorKim, KS-
dc.contributor.authorGhosh, A-
dc.contributor.authorByun, S-
dc.contributor.authorLee, CG-
dc.contributor.authorKang, HJ-
dc.contributor.authorKim, GC-
dc.contributor.authorJun, CD-
dc.contributor.authorJan, G-
dc.contributor.authorSuh, CH-
dc.contributor.authorJung, JY-
dc.contributor.authorSprent, J-
dc.contributor.authorRudra, D-
dc.contributor.authorDe Castro, C-
dc.contributor.authorMolinaro, A-
dc.contributor.authorSurh, CD-
dc.contributor.authorIm, SH-
dc.date.accessioned2019-11-13T04:28:27Z-
dc.date.available2019-11-13T04:28:27Z-
dc.date.issued2018-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/17710-
dc.description.abstractDysregulation of intestinal microflora is linked to inflammatory disorders associated with compromised immunosuppressive functions of Foxp3(+) T regulatory (Treg) cells. Although mucosa-associated commensal microbiota has been implicated in Treg generation, molecular identities of the "effector" components controlling this process remain largely unknown. Here, we have defined Bifidobacterium bifidum as a potent inducer of Foxp3(+) Treg cells with diverse T cell receptor specificity to dietary antigens, commensal bacteria, and B. bifidum itself. Cell surface beta-glucan/galactan (CSGG) polysaccharides of B. bifidum were identified as key components responsible for Treg induction. CSGG efficiently recapitulated the activity of whole bacteria and acted via regulatory dendritic cells through a partially Toll-like receptor 2-mediated mechanism. Treg cells induced by B. bifidum or purified CSGG display stable and robust suppressive capacity toward experimental colitis. By identifying CSGG as a functional component of Treg-inducing bacteria, our studies highlight the immunomodulatory potential of CSGG and CSGG-producing microbes.-
dc.language.isoen-
dc.titleCell surface polysaccharides of Bifidobacterium bifidum induce the generation of Foxp3(+) regulatory T cells-
dc.typeArticle-
dc.identifier.pmid30341145-
dc.contributor.affiliatedAuthor서, 창희-
dc.contributor.affiliatedAuthor정, 주양-
dc.type.localJournal Papers-
dc.identifier.doi10.1126/sciimmunol.aat6975-
dc.citation.titleScience immunology-
dc.citation.volume3-
dc.citation.number28-
dc.citation.date2018-
dc.citation.startPageeaat6975-
dc.citation.endPageeaat6975-
dc.identifier.bibliographicCitationScience immunology, 3(28):eaat6975-eaat6975, 2018-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn24709468-
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Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
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