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Cell surface polysaccharides of Bifidobacterium bifidum induce the generation of Foxp3(+) regulatory T cells

Authors
Verma, R | Lee, C | Jeun, EJ | Yi, J | Kim, KS | Ghosh, A | Byun, S | Lee, CG | Kang, HJ | Kim, GC | Jun, CD | Jan, G | Suh, CH  | Jung, JY  | Sprent, J | Rudra, D | De Castro, C | Molinaro, A | Surh, CD | Im, SH
Citation
Science immunology, 3(28). : eaat6975-eaat6975, 2018
Journal Title
Science immunology
ISSN
2470-9468
Abstract
Dysregulation of intestinal microflora is linked to inflammatory disorders associated with compromised immunosuppressive functions of Foxp3(+) T regulatory (Treg) cells. Although mucosa-associated commensal microbiota has been implicated in Treg generation, molecular identities of the "effector" components controlling this process remain largely unknown. Here, we have defined Bifidobacterium bifidum as a potent inducer of Foxp3(+) Treg cells with diverse T cell receptor specificity to dietary antigens, commensal bacteria, and B. bifidum itself. Cell surface beta-glucan/galactan (CSGG) polysaccharides of B. bifidum were identified as key components responsible for Treg induction. CSGG efficiently recapitulated the activity of whole bacteria and acted via regulatory dendritic cells through a partially Toll-like receptor 2-mediated mechanism. Treg cells induced by B. bifidum or purified CSGG display stable and robust suppressive capacity toward experimental colitis. By identifying CSGG as a functional component of Treg-inducing bacteria, our studies highlight the immunomodulatory potential of CSGG and CSGG-producing microbes.
DOI
10.1126/sciimmunol.aat6975
PMID
30341145
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
Ajou Authors
서, 창희  |  정, 주양
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