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Blood adiponectin levels are not associated with risk of cardiovascular events in patients with type 2 diabetes

Authors
Jeon, JY; Ha, KH; Han, SJ; Kim, HJ; Lee, KW; Kim, DJ
Citation
Diabetes & vascular disease research, 15(6):571-575, 2018
Journal Title
Diabetes & vascular disease research
ISSN
1479-16411752-8984
Abstract
INTRODUCTION: We examined whether circulating adiponectin levels are associated with further cardiovascular events in patients with type 2 diabetes.
METHODS: Between December 2004 and February 2005, 349 patients with type 2 diabetes were enrolled and followed-up until December 2015. Blood levels of total, middle-molecular weight and high-molecular weight adiponectin were measured at baseline. The primary composite outcome was the occurrence of the following events: cardiovascular death, non-fatal myocardial infarction, non-fatal stroke or hospitalization for unstable angina and heart failure.
RESULTS: During a median follow-up of 9 years, cardiovascular events occurred in 14% of patients (50/349, 1.9% per year). Median blood levels of total, middle-molecular weight and high-molecular weight adiponectin were 4.8, 3.2 and 1.8 mug/mL, respectively. The cumulative incidence of cardiovascular events was not significantly different between the three groups based on total, middle-molecular weight, high-molecular weight or high-molecular weight/total adiponectin. After adjustment for potential confounding factors, blood adiponectin levels were positively associated with an increased number of cardiovascular events, but between tertiles, there was no significant difference.
CONCLUSION: This observational cohort study suggested that blood adiponectin levels are not related to further cardiovascular events in patients with type 2 diabetes.
Keywords
Adiponectintype 2 diabetescardiovascular eventscohort study
MeSH terms
Adiponectin/blood*AdultAgedBiomarkers/bloodCardiovascular Diseases/blood*Cardiovascular Diseases/diagnosisCardiovascular Diseases/mortalityCardiovascular Diseases/therapyDiabetes Mellitus, Type 2/blood*Diabetes Mellitus, Type 2/diagnosisDiabetes Mellitus, Type 2/mortalityFemaleFollow-Up StudiesHospitalizationHumansMaleMiddle AgedMolecular WeightPrognosisRepublic of KoreaRisk Factors
DOI
10.1177/1479164118793349
PMID
30160532
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Endocrinology & Metabolism
AJOU Authors
전, 자영하, 경화한, 승진김, 혜진이, 관우김, 대중
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