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Glycated hemoglobin A1c as a screening test for detecting type 2 diabetes mellitus in obese children and adolescents

Authors
Yoon, JS; So, CH; Lee, HS; Hwang, JS
Citation
Journal of pediatric endocrinology & metabolism : JPEM, 31(5):503-506, 2018
Journal Title
Journal of pediatric endocrinology & metabolism : JPEM
ISSN
0334-018X2191-0251
Abstract
BACKGROUND: The diagnostic cutoff points for indicators of type 2 diabetes mellitus (T2DM) in the pediatric population have not been defined thus far.
METHODS: A retrospective, single-center study was conducted from April 2003 to May 2016. We enrolled 236 overweight or obese children and adolescents aged 4-17 years. Thirty-nine (26.9%) of 145 patients had T2DM according to the oral glucose tolerance test results.
RESULTS: A glycated hemoglobin (HbA1c) level of 6.5% had a sensitivity and specificity of 87.2% and 98.5%, respectively, for detecting T2DM. The optimal HbA1c cutoff level for T2DM was >6.2% (94.7% sensitivity, 95.5% specificity).
CONCLUSIONS: We observed that the use of an HbA1c level of 6.5% had a lower sensitivity for detecting T2DM than an HbA1c level of >6.2%.
Keywords
HbA1cobesitypediatricsscreeningtype 2 diabetes
MeSH terms
AdolescentBiomarkers/analysis*Body Mass IndexChildDiabetes Mellitus, Type 2/bloodDiabetes Mellitus, Type 2/diagnosis*Diabetes Mellitus, Type 2/etiologyFemaleFollow-Up StudiesGlucose Tolerance TestGlycated Hemoglobin A/analysis*HumansMaleMass Screening/methods*Obesity/complications*Overweight/complications*Prediabetic State/bloodPrediabetic State/diagnosis*Prediabetic State/etiologyPrognosisROC CurveRetrospective Studies
DOI
10.1515/jpem-2017-0463
PMID
29652667
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pediatrics & Adolescent Medicine
AJOU Authors
이, 해상황, 진순
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