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Cadmium stimulates the expression of vascular cell adhesion molecule-1 (VCAM-1) via p38 mitogen-activated protein kinase (MAPK) and JNK activation in cerebrovascular endothelial cells.

Authors
Park, SL | Kim, YM  | Ahn, JH | Lee, SH  | Baik, EJ  | Moon, CH  | Jung, YS
Citation
Journal of pharmacological sciences, 110(3). : 405-409, 2009
Journal Title
Journal of pharmacological sciences
ISSN
1347-86131347-8648
Abstract
In this study, we examined the effect of Cd on the expression of vascular cell adhesion molecule-1 (VCAM-1) and its mechanisms in bEnd.3 cells. The treatment with Cd increased protein and mRNA expressions of VCAM-1 and increased the phosphorylations of p38, JNK, and ERK. The Cd-induced VCAM-1 expression was significantly suppressed by either a specific p38 mitogen-activated protein kinase (MAPK) inhibitor (SB202190) or a JNK inhibitor (SP600125), but not by an ERK inhibitor (U0126). These results suggest that Cd induces the expression of VCAM-1, at least in part, via p38 and JNK pathways in bEnd.3 cells.
MeSH

PMID
19609071
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
Ajou Authors
김, 유미  |  문, 창현  |  백, 은주  |  이, 수환  |  정, 이숙
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