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Metabolic features and regulation in cell senescence

Authors
Kwon, SM  | Hong, SM  | Lee, YK  | Min, S | Yoon, G
Citation
BMB reports, 52(1). : 5-12, 2019
Journal Title
BMB reports
ISSN
1976-66961976-670X
Abstract
Organismal aging is accompanied by a host of progressive metabolic alterations and an accumulation of senescent cells, along with functional decline and the appearance of multiple diseases. This implies that the metabolic features of cell senescence may contribute to the organism's metabolic changes and be closely linked to age-associated diseases, especially metabolic syndromes. However, there is no clear understanding of senescent metabolic characteristics. Here, we review key metabolic features and regulators of cellular senescence, focusing on mitochondrial dysfunction and anabolic deregulation, and their link to other senescence phenotypes and aging. We further discuss the mechanistic involvement of the metabolic regulators mTOR, AMPK, and GSK3, proposing them as key metabolic switches for modulating senescence.
Keywords
MeSH

DOI
10.5483/BMBRep.2019.52.1.291
PMID
30526768
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
Journal Papers > School of Medicine / Graduate School of Medicine > Biochemistry & Molecular Biology
Journal Papers > Research Organization > Inflamm-aging Translational Research Center
Ajou Authors
권, 소미  |  윤, 계순  |  이, 영경  |  홍, 선미
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