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Accuracy and precision of proton density fat fraction measurement across field strengths and scan intervals: A phantom and human study

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dc.contributor.authorKim, HJ-
dc.contributor.authorCho, HJ-
dc.contributor.authorKim, B-
dc.contributor.authorYou, MW-
dc.contributor.authorLee, JH-
dc.contributor.authorHuh, J-
dc.contributor.authorKim, JK-
dc.date.accessioned2020-10-21T07:20:17Z-
dc.date.available2020-10-21T07:20:17Z-
dc.date.issued2019-
dc.identifier.issn1053-1807-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/18726-
dc.description.abstractBACKGROUND: Complex-based chemical shift imaging-based magnetic resonance imaging (CSE-MRI) is emerging as a preferred method for noninvasively quantifying proton density fat fraction (PDFF), a promising quantitative imaging biomarker (QIB) for longitudinal hepatic steatosis measurement.
PURPOSE: To determine linearity, bias, repeatability, and reproducibility of the PDFF measurement using CSE-MRI (CSE-PDFF) across scan intervals, MR field strengths, and readers in phantom and nonalcoholic fatty liver disease (NAFLD) patients.
STUDY TYPE: Institutional Review Board (IRB)-approved prospective.
SUBJECTS: Fat-water phantom and 20 adult patients.
FIELD STRENGTH/SEQUENCE: 1.5 T and 3.0 T MR systems and a commercially available CSE-MRI sequence (IDEAL-IQ).
ASSESSMENT: Two independent readers measured CSE-PDFF of fat-water phantom and NAFLD patients across two field strengths and scan intervals (same-day and 2-week) each and in a combination of both. MR spectroscopy-based PDFF (MRS-PDFF) was used as the reference standard for phantom PDFF.
STATISTICAL TESTS: Linearity and bias of measurement were evaluated by linear regression analysis and Bland-Altman plots, respectively. Repeatability and reproducibility were assessed by coefficient of variance and repeatability / reproducibility coefficients (RC). The intraclass correlation coefficient was used to validate intra- and interobserver agreements.
RESULTS: CSE-PDFF showed high linearity and small bias (-0.6-0.4 PDFF%) with 95% limits of agreement within +/-2.9 PDFF% across field strengths, 2-week interscan period, and readers in the clinical scans. CSE-PDFF was highly repeatable and reproducible both in phantom and clinical scans, with the largest observed RC across field strengths and 2-week interscan period being 3 PDFF%.
DATA CONCLUSION: CSE-PDFF is a robust QIB with high linearity, small bias, and excellent repeatability/reproducibility. A change of more than 3 PDFF% across field strengths within 2 weeks of scan interval likely reflects a true change, which is well within the clinically acceptable range.
LEVEL OF EVIDENCE: 3
TECHNICAL EFFICACY: Stage 2.
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dc.language.isoen-
dc.titleAccuracy and precision of proton density fat fraction measurement across field strengths and scan intervals: A phantom and human study-
dc.typeArticle-
dc.identifier.pmid30430684-
dc.subject.keywordMRI-
dc.subject.keywordmagnetic resonance imaging-
dc.subject.keywordnonalcoholic fatty liver disease-
dc.subject.keywordproton density fat fraction-
dc.contributor.affiliatedAuthor김, 혜진-
dc.contributor.affiliatedAuthor조, 효정-
dc.contributor.affiliatedAuthor김, 보현-
dc.contributor.affiliatedAuthor이, 제희-
dc.contributor.affiliatedAuthor허, 지미-
dc.contributor.affiliatedAuthor김, 재근-
dc.type.localJournal Papers-
dc.identifier.doi10.1002/jmri.26575-
dc.citation.titleJournal of magnetic resonance imaging : JMRI-
dc.citation.volume50-
dc.citation.number1-
dc.citation.date2019-
dc.citation.startPage305-
dc.citation.endPage314-
dc.identifier.bibliographicCitationJournal of magnetic resonance imaging : JMRI, 50(1). : 305-314, 2019-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1522-2586-
dc.relation.journalidJ010531807-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Radiology
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
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