Cited 16 times in

Accuracy and precision of proton density fat fraction measurement across field strengths and scan intervals: A phantom and human study

Authors
Kim, HJ  | Cho, HJ  | Kim, B  | You, MW | Lee, JH  | Huh, J  | Kim, JK
Citation
Journal of magnetic resonance imaging : JMRI, 50(1). : 305-314, 2019
Journal Title
Journal of magnetic resonance imaging : JMRI
ISSN
1053-18071522-2586
Abstract
BACKGROUND: Complex-based chemical shift imaging-based magnetic resonance imaging (CSE-MRI) is emerging as a preferred method for noninvasively quantifying proton density fat fraction (PDFF), a promising quantitative imaging biomarker (QIB) for longitudinal hepatic steatosis measurement.
PURPOSE: To determine linearity, bias, repeatability, and reproducibility of the PDFF measurement using CSE-MRI (CSE-PDFF) across scan intervals, MR field strengths, and readers in phantom and nonalcoholic fatty liver disease (NAFLD) patients.
STUDY TYPE: Institutional Review Board (IRB)-approved prospective.
SUBJECTS: Fat-water phantom and 20 adult patients.
FIELD STRENGTH/SEQUENCE: 1.5 T and 3.0 T MR systems and a commercially available CSE-MRI sequence (IDEAL-IQ).
ASSESSMENT: Two independent readers measured CSE-PDFF of fat-water phantom and NAFLD patients across two field strengths and scan intervals (same-day and 2-week) each and in a combination of both. MR spectroscopy-based PDFF (MRS-PDFF) was used as the reference standard for phantom PDFF.
STATISTICAL TESTS: Linearity and bias of measurement were evaluated by linear regression analysis and Bland-Altman plots, respectively. Repeatability and reproducibility were assessed by coefficient of variance and repeatability / reproducibility coefficients (RC). The intraclass correlation coefficient was used to validate intra- and interobserver agreements.
RESULTS: CSE-PDFF showed high linearity and small bias (-0.6-0.4 PDFF%) with 95% limits of agreement within +/-2.9 PDFF% across field strengths, 2-week interscan period, and readers in the clinical scans. CSE-PDFF was highly repeatable and reproducible both in phantom and clinical scans, with the largest observed RC across field strengths and 2-week interscan period being 3 PDFF%.
DATA CONCLUSION: CSE-PDFF is a robust QIB with high linearity, small bias, and excellent repeatability/reproducibility. A change of more than 3 PDFF% across field strengths within 2 weeks of scan interval likely reflects a true change, which is well within the clinically acceptable range.
LEVEL OF EVIDENCE: 3
TECHNICAL EFFICACY: Stage 2.
Keywords
DOI
10.1002/jmri.26575
PMID
30430684
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Radiology
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
Ajou Authors
김, 보현  |  김, 재근  |  김, 혜진  |  이, 제희  |  조, 효정  |  허, 지미
Files in This Item:
There are no files associated with this item.
Export

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse