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Senescent fibroblasts in melasma pathophysiology

Authors
Kim, M | Kim, SM | Kwon, S | Park, TJ  | Kang, HY
Citation
Experimental dermatology, 28(6). : 719-722, 2019
Journal Title
Experimental dermatology
ISSN
0906-67051600-0625
Abstract
It has been proposed that melasma is a photoageing skin disorder. The photoaged fibroblasts have been suggested as an important source of melanogenic factors which are involved in the regulation of pigmentation. To investigate whether melasma includes senescent cells, lesional and perilesional normal skin from 38 melasma patients was assessed using a cell senescence marker, p16(INK4A) . The results showed that lesional dermal skin had more p16(INK4A) -positive senescent cells than perilesional skin. The impact of senescent fibroblasts was further investigated in a pilot study using radiofrequency (RF) intervention for melasma. It showed that the RF therapy decreased the number of senescent cells with increased expression of procollagen-1, which were associated with reduced epidermal pigmentation. This leads us to the speculation that senescent fibroblasts may contribute to drive melasma and might be considered as a potential therapeutic target.
Keywords
MeSH

DOI
10.1111/exd.13814
PMID
30575141
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Biochemistry & Molecular Biology
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
Ajou Authors
강, 희영  |  박, 태준
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