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Cellular senescence in cancer

Authors
Kim, YH | Park, TJ
Citation
BMB reports, 52(1). : 42-46, 2019
Journal Title
BMB reports
ISSN
1976-66961976-670X
Abstract
Cellular senescence, a process of cell proliferation arrest in response to various stressors, has been considered to be important factor in age-related disease. Identification of senescent cells in tissues is limited and the role of senescent cells is poorly understood. Recently however, several studies showed the characterization of senescent cells in various pathologic conditions and the role of senescent cells in disease progression is becoming important. Senescent cells are growth-arrested cells, however, the senescence associated secretory phenotype (SASP) of senescent cells could modify the tissues' microenvironment. Here, we discuss the progress and understanding of the role of senescent cells in tissues of pathologic conditions and discuss the development of new therapeutic paradigms, such as senescent cells-targeted therapy.
Keywords
MeSH

DOI
10.5483/BMBRep.2019.52.1.295
PMID
30526772
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Biochemistry & Molecular Biology
Ajou Authors
박, 태준
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