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A 3D Microscaffold Cochlear Electrode Array for Steroid Elution

Authors
Jang, J | Kim, JY | Kim, YC | Kim, S | Chou, N | Lee, S | Choung, YH  | Kim, S | Brugger, J | Choi, H | Jang, JH
Citation
Advanced healthcare materials, 8(20). : e1900379-e1900379, 2019
Journal Title
Advanced healthcare materials
ISSN
2192-26402192-2659
Abstract
In cochlear implants, the electrode insertion trauma during surgery can cause damage residual hearing. Preserving the residual hearing is an important challenge and the localized administration of drugs, such as steroids, is one of the most promising ways, but remains a challenge. Here, a microscaffold cochlear electrode array (MiSCEA) consisting of a microfabricated flexible electrode array and a 3D microscaffold for steroid reservoir is reported. The MiSCEA without loaded drug is tested by measuring the electrically evoked auditory brainstem response of the cochlea in guinea pigs (n = 4). The scaffold is then coated with steroid (dexamethasone) encapsulated in polylactic-co-glycolic acid and the continuous release of the steroid into artificial perilymph during six weeks is monitored. The steroid-containing scaffolds are then implanted into guinea pigs (n = 4) and threshold shifts are analyzed for four weeks by measuring the acoustically evoked auditory brainstem response. The threshold shifts tend to be lower in the group implanted with the steroid-containing MiSCEAs. The feasibility of 3D MiSCEA opens up the development of potential next-generation cochlear electrode with improved steroid release dynamics into cochlea.
Keywords
MeSH

DOI
10.1002/adhm.201900379
PMID
31532887
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Otolaryngology
Ajou Authors
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