BACKGROUND: The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) are indicators of systemic inflammation and are useful as markers in systemic rheumatic diseases. In this study, we compared the NLR, PLR, and MLR among patients with polymyalgia rheumatica (PMR) and rheumatoid arthritis (RA), and explored possible associations with clinical features, disease activity, and prognosis in patients with PMR.
METHODS: The study enrolled 94 patients with PMR and 242 patients with RA who were initially diagnosed at the rheumatology clinic of a university-based tertiary hospital. Symptoms, physical examination, and medical histories were collected with the results of laboratory tests.
RESULTS: Neutrophil-to-lymphocyte ratio (4.5 +/- 3.3 vs 2.8 +/- 1.8), PLR (222.7 +/- 115.5 vs 159.7 +/- 78.1), and MLR (0.4 +/- 0.3 vs 0.3 +/- 0.2) were higher in patients with PMR compared with patients with RA (all P < .001). NLR, PLR, and MLR were correlated with specific laboratory values, including CRP and albumin, in patients with PMR. After disease activity resolved, NLR (2.95 +/- 2.32, P < .001), PLR (137.5 +/- 82.3, P < .001), and MLR (0.26 +/- 0.16, P < .001) decreased significantly. By comparing patients according to the disease course, swollen joint counts were higher in the chronic course group compared with the remission group (P = .03), while the NLR, PLR, and MLR were similar.
CONCLUSIONS: Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio levels were associated with disease activity and specific clinical features, although they could not predict prognosis in patients with PMR.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
Total Visit :9,766,351
Total Download :4,090,236
Today View :953
Ajou University Medical Information & Media Center 164 Worldcup-ro Yeongtong-gu Suwon 16499 Korea / TEL : 031-219-5312 / FAX : 031-219-5314 Copyright (c) Ajou University Medical Information & Media Center All Rights Reserved. AJOU Open Repository는 국립중앙도서관 OAK 보급사업으로 구축되었습니다.