Cited 0 times in Scipus Cited Count

Uric acid is a useful marker to differentiate between responsive and refractory status epilepticus

DC Field Value Language
dc.contributor.authorChoi, JY-
dc.contributor.authorHong, JM-
dc.contributor.authorKim, TJ-
dc.contributor.authorKim, BG-
dc.contributor.authorHuh, K-
dc.date.accessioned2020-11-17T05:29:34Z-
dc.date.available2020-11-17T05:29:34Z-
dc.date.issued2019-
dc.identifier.issn0303-8467-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/19061-
dc.description.abstractOBJECTIVES: Early recognition of refractory status epilepticus (RSE) is essential to select an appropriate treatment strategy and is closely associated with the outcome. Only few studies of RSE biomarkers exist: hence, we investigated the serum levels of uric acid (UA), albumin, and C-reactive protein (CRP) as potential serologic biomarkers for RSE.
PATIENTS AND METHODS: Consecutive status epilepticus (SE) patients who had serial conventional blood tests in a referral hospital over a period of 10 years were retrospectively analyzed. Patients with anoxic encephalopathy, renal failure, acute stroke, and myocardial infarction were excluded. RSE was defined as seizure continuing after the first- and second-line treatments. We also assessed SE severity in all included patients using the Status Epilepticus Severity Score (STESS). General demographics and blood test findings were compared between responsive SE and RSE patients.
RESULTS: A total of 141 patients (99 responsive and 42 refractory) were recruited from our SE registry. Compared to responsive patients, patients with RSE showed a higher STESS, lower initial albumin levels, lower initial UA levels, lower follow-up UA levels, and greater reduction of UA levels. The RSE group more frequently had acute symptomatic etiology, showed longer hospitalization, and had poorer functional outcomes compared to the responsive-SE group. All evaluated UA level parameters exhibited significant areas under the curve in receiver operating characteristic analyses, predictive of RSE. Initial UA levels, as well as changes therein, were significantly associated with RSE in multivariate logistic regression analysis.
CONCLUSION: UA levels at initial and follow-up evaluations, and changes therein differentiated responsive SE and RSE, demonstrating the feasibility of UA serum levels as a biomarker for RSE.
-
dc.language.isoen-
dc.titleUric acid is a useful marker to differentiate between responsive and refractory status epilepticus-
dc.typeArticle-
dc.identifier.pmid31376771-
dc.subject.keywordAlbumin-
dc.subject.keywordBiomarkers-
dc.subject.keywordC-reactive protein-
dc.subject.keywordRefractory status epilepticus-
dc.subject.keywordStatus Epilepticus Severity Score (STESS)-
dc.subject.keywordUric acid-
dc.contributor.affiliatedAuthor최, 준영-
dc.contributor.affiliatedAuthor홍, 지만-
dc.contributor.affiliatedAuthor김, 태준-
dc.contributor.affiliatedAuthor김, 병곤-
dc.contributor.affiliatedAuthor허, 균-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.clineuro.2019.105454-
dc.citation.titleClinical neurology and neurosurgery-
dc.citation.volume184-
dc.citation.date2019-
dc.citation.startPage105454-
dc.citation.endPage105454-
dc.identifier.bibliographicCitationClinical neurology and neurosurgery, 184. : 105454-105454, 2019-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1872-6968-
dc.relation.journalidJ003038467-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Brain Science
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Humanities & Social Medicine
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse