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Effect of distal protection device on the microvascular integrity in acute myocardial infarction during primary percutaneous coronary intervention.

Authors
Yoon, MH; Tahk, SJ; Choi, SY; Choi, TY; Choi, BJ; Choi, JH; Yoo, SY; Ahn, SG; Zheng, ZG; Hwang, GS; Shin, JH
Citation
Circulation journal : official journal of the Japanese Circulation Society, 70(10):1284-1289, 2006
Journal Title
Circulation journal : official journal of the Japanese Circulation Society
ISSN
1346-98431347-4820
Abstract
BACKGROUND: The use of a distal protection device during primary percutaneous coronary intervention (PCI) in acute myocardial infarction (AMI) may preserve the microvascular integrity of the myocardium.



METHODS AND RESULTS: A total of 58 consecutive patients with AMI, who had undergone primary PCI within 24 h after onset, were enrolled (30 patients with the PercuSurge GuardWire System, 28 without). The coronary flow velocity reserve was not different between the 2 groups. In patients with a distal protection device, the post-PCI Thrombolysis In Myocardial Infarction myocardial perfusion grades (TMP) were more favorable (TMP 0/1: 13.3%, TMP 2: 23.3%, TMP 3: 63.4% vs TMP 0/1: 35.7%, TMP 2: 35.7%, TMP 3: 28.6%, p=0.023). These patients also exhibited lower basal and hyperemic microvascular resistance index levels (4.33+/-2.22 vs 5.55+/-2.36 mmHg . cm(-1) . s, p=0.047; 2.39+/-1.40 vs 3.14+/-1.36 mmHg . cm(-1) . s, p=0.045, respectively), and longer basal diastolic deceleration time (679+/-273 vs 519+/-289 ms, p=0.035) after PCI.



CONCLUSION: Distal protection with the PercuSurge GuardWire system may effectively preserve the microvascular integrity of the myocardium during primary PCI in AMI patients.
MeSH terms
AdultAgedAngioplasty, Balloon, Coronary/adverse effectsAngioplasty, Balloon, Coronary/methods*Blood Flow VelocityCoronary Vessels/physiopathology*Equipment and Supplies/standards*FemaleHumansMaleMicrocirculation/physiopathologyMiddle AgedMyocardial Infarction/therapy*
PMID
16998260
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Cardiology
AJOU Authors
윤, 명호탁, 승제최, 소연최, 병주황, 교승신, 준한
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