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Lymphopenia as a Potential Predictor of Ipsilateral Breast Tumor Recurrence in Early Breast Cancer

Authors
Cho, O  | Chun, M  | Kim, SW | Jung, YS  | Yim, H
Citation
Anticancer research, 39(8). : 4467-4474, 2019
Journal Title
Anticancer research
ISSN
0250-70051791-7530
Abstract
BACKGROUND/AIM: The aim of this study was to investigate the association between lymphopenia after breast conserving therapy (BCT) and ipsilateral breast tumor recurrence (IBTR) in early breast cancer (EBC).
PATIENTS AND METHODS: We examined 216 EBC patients treated with partial mastectomy followed by radiotherapy (RT), none of whom received chemotherapy. Absolute lymphocyte counts (ALCs) during the two years after RT were collected from each patient: pretreatment ALC, ALC at 3-5 months (ALC1), ALC at 9-11 months, ALC at 15-17 months, and ALC at 21-23 months.
RESULTS: The 102 patients with ALC1 1,479 cells/mul (16.2% vs. 1%, p=0.0034). The multivariate analysis showed that age, resection margins, human epidermal growth factor receptor, and lymphopenia were significant predictors of IBTR.
CONCLUSION: Lymphopenia is a potential predictor for IBTR in EBC patients treated with BCT.
Keywords
MeSH

DOI
10.21873/anticanres.13620
PMID
31366546
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Radiation Oncology
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Ajou Authors
임, 현이  |  전, 미선  |  정, 용식  |  조, 오연
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