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Differences in Expression of Human Leukocyte Antigen Class II Subtypes and T Cell Subsets in Behcet's Disease with Arthritis

Authors
Islam, SMS | Kim, HA  | Choi, B | Jung, JY  | Lee, SM | Suh, CH  | Sohn, S
Citation
International journal of molecular sciences, 20(20). : 5044-5044, 2019
Journal Title
International journal of molecular sciences
ISSN
1422-0067
Abstract
It has been reported Human Leukocyte Antigen (HLA) gene polymorphism is a risk factor for the development of Behcet's disease (BD). In this study, the association of HLA class II subtypes HLA-DP, DQ, DR, and T cell subsets in BD patients with arthritis was evaluated. Frequencies of HLA-DP, DQ, DR positive cells, and T cell subsets in peripheral blood leukocytes (PBL) were measured by flow cytometric analysis in BD, and compared to rheumatoid arthritis as disease controls and healthy controls. Frequencies of HLA-DQ were significantly decreased in whole PBL and granulocytes of BD active patients as compared to healthy controls. In monocytes populations, proportions of HLA-DR positive cells were significantly increased in BD active patients as compared to healthy controls. Proportions of CD4+CCR7+ and CD8+CCR7+ cells were significantly higher in BD active patients than in BD inactive in whole PBL. Frequencies of CD4+CD62L- and CD8+CD62L- cells in lymphocytes were significantly decreased in active BD than those in inactive BD. There were also correlations between disease activity markers and T cell subsets. Our results revealed HLA-DP, DQ, and DR expressing cell frequencies and several T cell subsets were significantly correlated with BD arthritis symptoms.
Keywords
MeSH

DOI
10.3390/ijms20205044
PMID
31614573
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
Journal Papers > School of Medicine / Graduate School of Medicine > Microbiology
Ajou Authors
김, 현아  |  서, 창희  |  손, 성향  |  정, 주양
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