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Acute exacerbation of idiopathic pulmonary fibrosis: frequency and clinical features.

Kim, DS; Park, JH; Park, BK; Lee, JS; Nicholson, AG; Colby, T
The European respiratory journal, 27(1):143-150, 2006
Journal Title
The European respiratory journal
Although acute exacerbations of idiopathic pulmonary fibrosis are well recognised, there are no studies documenting their prevalence or identifying pre-existing risk factors. This study analysed the clinical, radiological and pathological data of 11 patients who satisfied the criteria for acute exacerbation among 147 patients with biopsy-proven idiopathic pulmonary fibrosis. There were five additional patients who had similar demographics, radiology and surgical lung biopsy pathology, but had clinically less severe disease, and so were not included. The 2-yr frequency of acute exacerbation was 9.6% after the diagnosis. Most exacerbations were idiopathic, although two cases presented after surgical lung biopsy and one after bronchoalveolar lavage. No significant risk factor was found by univariate proportional hazard analysis. Imaging revealed diffuse bilateral ground-glass opacification superimposed on subpleural reticular and honeycombing densities. The biopsies of four patients taken during acute exacerbation exhibited diffuse alveolar damage superimposed upon usual interstitial pneumonia. The findings of this study demonstrate that acute exacerbation of idiopathic pulmonary fibrosis is rather common and this exacerbation is likely to have a spectrum of severity.
MeSH terms
Acute DiseaseBronchoalveolar LavageChi-Square DistributionFemaleHumansMaleMiddle AgedPrevalenceProportional Hazards ModelsPulmonary Fibrosis/pathology*Pulmonary Fibrosis/physiopathologyPulmonary Fibrosis/radiographyRetrospective StudiesRisk FactorsSpirometryTomography, X-Ray Computed
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Journal Papers > School of Medicine / Graduate School of Medicine > Pulmonary & Critical Care Medicine
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박, 주헌
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